INT12681

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Context Info
Confidence 0.53
First Reported 1984
Last Reported 2010
Negated 5
Speculated 6
Reported most in Abstract
Documents 76
Total Number 82
Disease Relevance 23.92
Pain Relevance 26.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Trib3) nucleus (Trib3) enzyme binding (Trib3)
kinase activity (Trib3)
Anatomy Link Frequency
nucleus 3
neurons 3
brain 2
blood 2
spinal cord 2
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 182 100.00 Very High Very High Very High
substance P 174 100.00 Very High Very High Very High
Dopamine 98 100.00 Very High Very High Very High
long-term potentiation 49 100.00 Very High Very High Very High
opioid receptor 33 100.00 Very High Very High Very High
anesthesia 32 100.00 Very High Very High Very High
adenocard 20 100.00 Very High Very High Very High
antagonist 106 99.82 Very High Very High Very High
Inflammatory stimuli 2 99.82 Very High Very High Very High
Desipramine 13 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 4 99.98 Very High Very High Very High
Hypertrophy 41 99.92 Very High Very High Very High
Amnesia 6 99.72 Very High Very High Very High
INFLAMMATION 335 99.64 Very High Very High Very High
Pain 407 99.46 Very High Very High Very High
Neurodegenerative Disease 29 99.42 Very High Very High Very High
Disease 256 99.12 Very High Very High Very High
Experimental Autoimmune Neuritis 1 99.08 Very High Very High Very High
Death 178 98.88 Very High Very High Very High
Ganglion Cysts 79 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Muscular cell proliferative and protective effects of N-acetylcysteine by modulating activity of extracellular signal-regulated protein kinase.
Regulation (modulating) of kinase
1) Confidence 0.53 Published 2006 Journal Life Sci. Section Title Doc Link 16574161 Disease Relevance 0.09 Pain Relevance 0.06
Antidepressants and protein kinases: desipramine treatment affects pineal gland cAMP-dependent protein kinase activity.
Regulation (affects) of kinase in pineal gland associated with desipramine and antidepressant
2) Confidence 0.23 Published 1986 Journal Eur. J. Pharmacol. Section Title Doc Link 2937646 Disease Relevance 0 Pain Relevance 0.45
Since NO production may play a role in the pathogenesis of experimental neuro-immunological disorders like experimental autoimmune encephalomyelitis and experimental autoimmune neuritis, our findings suggest a possible therapeutic role for tyrosine kinase inhibitors.
Spec (possible) Regulation (role) of kinase associated with multiple sclerosis, experimental autoimmune neuritis and neuritis
3) Confidence 0.21 Published 1996 Journal Neurochem. Int. Section Abstract Doc Link 8808792 Disease Relevance 0.39 Pain Relevance 0.49
The enhanced effect of urethane anesthesia on the serum creatine kinase (CPK) level following administration of hypolipidemic agents was examined to develop a convenient experimental screening method for drug-induced myopathy.
Spec (examined) Regulation (effect) of kinase associated with anesthesia and muscle disease
4) Confidence 0.13 Published 1997 Journal Biol. Pharm. Bull. Section Abstract Doc Link 9013820 Disease Relevance 0.24 Pain Relevance 0.17
At the same time, pretreatment with mu-OR antagonists did not affect the level of creatine kinase in the coronary effluent.
Neg (not) Regulation (affect) of kinase associated with antagonist
5) Confidence 0.13 Published 2004 Journal Eksp Klin Farmakol Section Abstract Doc Link 15707010 Disease Relevance 0.18 Pain Relevance 0.39
In contrast, prazosin and the protein kinase C inhibitors chelerythrine and bisindolylmaleimide I were ineffective.
Regulation (ineffective) of kinase
6) Confidence 0.10 Published 2005 Journal Anesthesiology Section Body Doc Link 16249671 Disease Relevance 0 Pain Relevance 0
Effects of glycogen synthase kinase 3beta and cyclin-dependent kinase 5 inhibitors on morphine-induced analgesia and tolerance in rats.
Regulation (Effects) of kinase associated with tolerance, analgesia and morphine
7) Confidence 0.09 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16902054 Disease Relevance 0 Pain Relevance 1.36
Injection of pentobarbital also resulted in decreased 6-phosphofructo 2-kinase activity and increased fructose 2,6-bisphosphatase activity measured in dialyzed (NH4)2SO4-treated liver extracts but with no change in pyruvate kinase activity.
Neg (no) Regulation (change) of kinase in liver
8) Confidence 0.09 Published 1984 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 6089777 Disease Relevance 0 Pain Relevance 0.17
Agents that act on calcium/calmodulin kinase cause amnesia in the ITM range--15 to 30 min post-training.
Regulation (act) of kinase associated with amnesia
9) Confidence 0.08 Published 1993 Journal Behav. Brain Res. Section Abstract Doc Link 8117424 Disease Relevance 0.26 Pain Relevance 0.07
Adenosine kinase (AK; EC 2.7.1.20) is a key intracellular enzyme regulating intra-and extracellular concentrations of adenosine (ADO), an endogenous neuromodulator, antinociceptive, and anti-inflammatory autocoid.
Regulation (regulating) of kinase associated with adenocard, inflammation and antinociceptive
10) Confidence 0.07 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11082454 Disease Relevance 0.48 Pain Relevance 0.63
SB 203580 [a p38 mitogen-activated protein kinase (p38 MAPK) inhibitor] and PD 98059 (a p44/42 MAPK kinase inhibitor) were ineffective in modulating IL-1beta-induced SP synthesis and secretion, and p60c-src kinase activity in DRG neurons.
Regulation (modulating) of kinase in DRG associated with substance p
11) Confidence 0.07 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622206 Disease Relevance 0 Pain Relevance 0.50
Down regulation involved phosphorylation and at least two different kinases, a tyrosine kinase (TK) and MAPK kinase (MEK), mediated DOR down regulation in parallel routes.
Regulation (regulation) of kinase associated with opioid receptor
12) Confidence 0.06 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11731019 Disease Relevance 0 Pain Relevance 0.57
Down regulation involved phosphorylation and at least two different kinases, a tyrosine kinase (TK) and MAPK kinase (MEK), mediated DOR down regulation in parallel routes.
Regulation (regulation) of kinase associated with opioid receptor
13) Confidence 0.06 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11731019 Disease Relevance 0 Pain Relevance 0.57
The increase in GABA release was also shown to be protein kinase C-dependent.
Regulation (dependent) of kinase associated with kinase c and gaba
14) Confidence 0.06 Published 2004 Journal Neuroscience Section Abstract Doc Link 15262336 Disease Relevance 0 Pain Relevance 0.60
The first objective of this work was to examine the effect of protein kinase A (PKA) and protein kinase C (PKC) inhibitors on morphine withdrawal-induced changes in corticosterone release (an index of the hypothalamus-pituitary-adrenocortical axis activity) and in catecholaminergic turnover in the paraventricular nucleus.
Spec (examine) Regulation (effect) of kinase in nucleus associated with kinase c, withdrawal and morphine
15) Confidence 0.06 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12323385 Disease Relevance 0 Pain Relevance 0.56
The first objective of this work was to examine the effect of protein kinase A (PKA) and protein kinase C (PKC) inhibitors on morphine withdrawal-induced changes in corticosterone release (an index of the hypothalamus-pituitary-adrenocortical axis activity) and in catecholaminergic turnover in the paraventricular nucleus.
Spec (examine) Regulation (effect) of kinase in nucleus associated with kinase c, withdrawal and morphine
16) Confidence 0.06 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12323385 Disease Relevance 0 Pain Relevance 0.57
DMP696 modulated DRP2, pyruvate kinase, LDH and ATP synthase.
Regulation (modulated) of kinase
17) Confidence 0.06 Published 2006 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 16517129 Disease Relevance 0.15 Pain Relevance 0.68
We found a small number of phosphorylated extracellular signal-regulated kinase (pERK)-labelled neurons in laminae I-II and III-IV of the spinal dorsal horn in the control rats after 0.1 mA stimulation.
Regulation (regulated) of kinase in neurons associated with spinal dorsal horn
18) Confidence 0.06 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15009135 Disease Relevance 0.65 Pain Relevance 0.33
In contrast, chronic morphine treatment did not alter protein kinase activity in several other brain regions studied, including the neostriatum, frontal cortex, and dorsal raphe.
Neg (not) Regulation (alter) of kinase in brain associated with urological neuroanatomy, raphe and morphine
19) Confidence 0.05 Published 1988 Journal Mol. Pharmacol. Section Abstract Doc Link 3340078 Disease Relevance 0.16 Pain Relevance 1.22
A tyrosine kinase signaling pathway, regulated by calcium entry and dissociated from tyrosine phosphorylation of phospholipase Cgamma-1, is involved in inositol phosphate production by activated G protein-coupled receptors in myometrium.
Regulation (regulated) of kinase in myometrium
20) Confidence 0.05 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 10215683 Disease Relevance 0.08 Pain Relevance 0.15

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