INT126812

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 0.81
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Cttn) cytoplasm (Cttn)
Anatomy Link Frequency
platelets 3
megakaryocytes 2
tail 1
hippocampus 1
T-cells 1
Cttn (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 24 100.00 Very High Very High Very High
tail-flick 1 99.86 Very High Very High Very High
antinociception 5 98.96 Very High Very High Very High
Antinociceptive 2 98.16 Very High Very High Very High
narcan 1 97.36 Very High Very High Very High
Potency 3 95.08 Very High Very High Very High
agonist 48 94.76 High High
mu opioid receptor 2 92.96 High High
IPN 1 79.44 Quite High
opioid receptor 1 71.96 Quite High
Disease Link Frequency Relevance Heat
Cicatrix 42 99.92 Very High Very High Very High
Wiskott-aldrich Syndrome 1 99.16 Very High Very High Very High
Inflammatory Pain 1 79.44 Quite High
Targeted Disruption 92 71.72 Quite High
Stress 31 59.80 Quite High
Thrombosis 35 55.44 Quite High
Injury 15 44.36 Quite Low
Adhesions 22 43.68 Quite Low
Hemorrhage 35 41.48 Quite Low
Apoptosis 13 34.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of several other genes whose products interact with actin filaments or microtubules in the growth cone was also up-regulated in Glud1 mouse hippocampus, including Actr3 (Actin-Related Protein 3), Cttn (Cortactin), and Wasl (Wiskott-Aldrich Syndrome-Like).
Gene_expression (expression) of Cortactin in hippocampus associated with wiskott-aldrich syndrome and hippocampus
1) Confidence 0.57 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.17 Pain Relevance 0.11
The expression of cortactin, Scar/WAVE2 and WASp was the same in both WT and HS1-/- platelets indicating that there was no compensatory up-regulation of these proteins (Figure 2E).
Gene_expression (expression) of cortactin in platelets associated with cicatrix
2) Confidence 0.53 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.51 Pain Relevance 0
In contrast, B and T-cells, which show a distinct phenotype in the absence of HS1, express a low level of cortactin.
Gene_expression (express) of cortactin in T-cells
3) Confidence 0.53 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0 Pain Relevance 0
It is possible that cortactin and HS1 could be functionally redundant as they share a very similar domain structure and that cortactin is highly expressed in megakaryocytes and platelets [24].
Gene_expression (expressed) of cortactin in platelets
4) Confidence 0.53 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0 Pain Relevance 0
HS1 is expressed in cells of a haematopoietic lineage, whereas cortactin is ubiquitously expressed.
Gene_expression (expressed) of cortactin
5) Confidence 0.53 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.06 Pain Relevance 0
It is possible that cortactin and HS1 could be functionally redundant as they share a very similar domain structure and that cortactin is highly expressed in megakaryocytes and platelets [24].
Gene_expression (expressed) of cortactin in platelets
6) Confidence 0.46 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0 Pain Relevance 0.03
It is possible that cortactin and HS1 could be functionally redundant as they share a very similar domain structure and that cortactin is highly expressed in megakaryocytes and platelets [24].
Gene_expression (expressed) of cortactin in megakaryocytes
7) Confidence 0.18 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0 Pain Relevance 0
It is possible that cortactin and HS1 could be functionally redundant as they share a very similar domain structure and that cortactin is highly expressed in megakaryocytes and platelets [24].
Gene_expression (expressed) of cortactin in megakaryocytes
8) Confidence 0.16 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0 Pain Relevance 0.03
In the mice tail-flick test, EMs[psi] (1, 5, 10 nmol/mouse, i.c.v.) produced potent and short-lasting antinociception in a dose-dependent and naloxone (1 mg/kg) reversed manner.
Gene_expression (produced) of EMs in tail associated with antinociception, narcan and tail-flick
9) Confidence 0.06 Published 2005 Journal Life Sci. Section Abstract Doc Link 15878600 Disease Relevance 0.08 Pain Relevance 1.07

General Comments

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