INT126813

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpc3)
Anatomy Link Frequency
cardiomyocytes 1
Muscle tissues 1
aorta 1
Trpc3 (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 2 96.48 Very High Very High Very High
TRP channel 100 95.44 Very High Very High Very High
agonist 8 95.00 High High
opioid receptor 1 94.64 High High
Potency 3 84.88 Quite High
antinociception 5 83.92 Quite High
mu opioid receptor 2 72.16 Quite High
tail-flick 1 58.00 Quite High
narcan 1 47.60 Quite Low
IPN 1 32.32 Quite Low
Disease Link Frequency Relevance Heat
Natriuresis 5 50.00 Quite Low
Inflammatory Pain 1 32.32 Quite Low
Hypertension 3 17.88 Low Low
Sprains And Strains 34 15.12 Low Low
Coronary Heart Disease 17 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Hypertrophy 4 5.00 Very Low Very Low Very Low
Subacute Sclerosing Panencephalitis 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the mu-selective pocket of endomorphins (EMs), Pro2 residue is a spacer and directs the Tyr1 and Trp3/Phe3 side chains into the required orientation.
Positive_regulation (directs) of Trp3
1) Confidence 0.67 Published 2005 Journal Life Sci. Section Abstract Doc Link 15878600 Disease Relevance 0 Pain Relevance 0.71
Muscle tissues, aorta (col 13), heart (col 15) uterus (col 10) and skeletal muscle (col 5) were positive for few TRP mRNAs, in particular TRPC3 and TRPV4, but the signals were relatively weak.
Positive_regulation (positive) of TRPC3 in Muscle tissues
2) Confidence 0.41 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.26
Studies in neonatal rat cardiomyocytes have indicated that Ang II induces TRPC3/C6 activation through G?
Positive_regulation (activation) of TRPC3 in cardiomyocytes
3) Confidence 0.39 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0
Muscle tissues, aorta (col 13), heart (col 15) uterus (col 10) and skeletal muscle (col 5) were positive for few TRP mRNAs, in particular TRPC3 and TRPV4, but the signals were relatively weak.
Positive_regulation (positive) of TRPC3 in aorta
4) Confidence 0.14 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.26

General Comments

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