INT126831

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Context Info
Confidence 0.05
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.88
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprk1) mRNA processing (Rbm39) RNA binding (Rbm39)
nucleus (Rbm39) plasma membrane (Oprk1) signal transducer activity (Oprk1)
Oprk1 (Mus musculus)
Rbm39 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 7 100.00 Very High Very High Very High
Kappa opioid receptor 6 100.00 Very High Very High Very High
opioid receptor 3 100.00 Very High Very High Very High
Antinociceptive 4 99.60 Very High Very High Very High
Potency 1 92.20 High High
Intracerebroventricular 1 84.28 Quite High
intrathecal 1 82.68 Quite High
antinociception 2 81.76 Quite High
tail-flick 1 80.68 Quite High
Central nervous system 3 79.12 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 11 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, the antinociceptive effects of the new kappa-opioid receptor agonist TRK-820, which has high affinity for kappa(2)- and/or kappa(3)-opioid receptors, injected both i.c.v. and i.t. in diabetic mice were markedly less than those in non-diabetic mice.
kappa-opioid receptor Binding (affinity) of receptors associated with diabetes mellitus, agonist, kappa opioid receptor, opioid receptor and antinociceptive
1) Confidence 0.05 Published 2005 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15879680 Disease Relevance 0.88 Pain Relevance 1.33

General Comments

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