INT126847

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 6.47
Pain Relevance 5.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
neuronal 4
spinal cord 2
synapses 2
neurons 1
neurite 1
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 47 99.84 Very High Very High Very High
allodynia 37 99.00 Very High Very High Very High
Hyperalgesia 55 98.44 Very High Very High Very High
Dorsal horn 58 97.88 Very High Very High Very High
opioid receptor 7 97.80 Very High Very High Very High
Inflammation 57 96.80 Very High Very High Very High
long-term potentiation 20 96.48 Very High Very High Very High
Spinal cord 148 96.20 Very High Very High Very High
Thermal hyperalgesia 52 95.80 Very High Very High Very High
Pain 142 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 93 99.84 Very High Very High Very High
Death 2 99.72 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

16 99.60 Very High Very High Very High
Nervous System Injury 20 99.48 Very High Very High Very High
Hyperalgesia 111 98.44 Very High Very High Very High
Neuroleptic Malignant Syndrome 18 97.24 Very High Very High Very High
INFLAMMATION 53 96.80 Very High Very High Very High
Injury 34 96.40 Very High Very High Very High
Stress 4 95.76 Very High Very High Very High
Pain 171 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ERK is associated with neuronal signal transduction and nociception.
ERK Binding (associated) of in neuronal
1) Confidence 0.46 Published 2006 Journal Spine Section Body Doc Link 16508545 Disease Relevance 0.18 Pain Relevance 0
A role for EphB1-ephrinB2 interactions in neuropathic pain has recently been identified, providing further support to the hypothesis that this receptor is the main contributor to synaptic plasticity of excitatory synapses in the spinal cord (Kobayashi et al., 2007; Song et al., 2008a,b).
EphB1-ephrinB2 Binding (interactions) of in synapses associated with neuropathic pain and spinal cord
2) Confidence 0.40 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.58 Pain Relevance 0.55
Each kinase inhibitor significantly attenuated the ligation-associated activation of ERK1/2 as well.
ERK Binding (ligation-associated) of
3) Confidence 0.36 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15882794 Disease Relevance 0.15 Pain Relevance 0.41
As for ERK, its role in neurite extension in response to growth factors is well-recognized.
ERK Binding (recognized) of in neurite
4) Confidence 0.35 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.36 Pain Relevance 0.26
Traditionally, ERK are associated with the regulation of proliferation and differentiation as well as survival of various cell types.
ERK Binding (associated) of
5) Confidence 0.35 Published 2007 Journal Current Neuropharmacology Section Abstract Doc Link PMC2644492 Disease Relevance 0.07 Pain Relevance 0.13
Moreover, ERK is associated with the upregulated central neuronal sensitivity to noxious CRD in NMS rats, which may be responsible for the behavioral hyperalgesia in NMS rat.
ERK Binding (associated) of in neuronal associated with hyperalgesia and neuroleptic malignant syndrome
6) Confidence 0.31 Published 2009 Journal J. Mol. Neurosci. Section Abstract Doc Link 18649147 Disease Relevance 0.69 Pain Relevance 0.49
The present study aims to investigate whether ERK associates with the colorectal distension (CRD)-evoked neuronal response and the upregulated central sensitivity to CRD in NMS rats.
ERK Binding (associates) of in neuronal associated with neuroleptic malignant syndrome
7) Confidence 0.31 Published 2009 Journal J. Mol. Neurosci. Section Abstract Doc Link 18649147 Disease Relevance 0.79 Pain Relevance 0.47
Exogenous activation of PKA with forskolin was used to determine the interaction with ERK.
ERK Binding (interaction) of
8) Confidence 0.30 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.17 Pain Relevance 0.16
Taken together these findings support the hypothesis that EphB–ephrinB interactions play an important role in NMDA-dependent, activity-dependent synaptic plasticity in the adult spinal cord, inducing the phosphorylation of the NR2B subunit of the receptor via Src family kinases, thus contributing to chronic pain states.



EphB Binding (interactions) of in spinal cord associated with lasting pain and spinal cord
9) Confidence 0.30 Published 2008 Journal Neuroscience Section Abstract Doc Link PMC2568875 Disease Relevance 0.67 Pain Relevance 0.70
We previously demonstrated that ephrinB2 induces a hyperalgesic response and that carrageenan-induced hyperalgesia could be reduced with a soluble Eph-B1 chimera, which, however, due to the promiscuous binding of EphB receptors, could block the activation by endogenous ephrinB2 of any EphB receptor present in the spinal cord.
EphB Binding (binding) of in spinal cord associated with hyperalgesia and spinal cord
10) Confidence 0.30 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.49 Pain Relevance 0.50
Indeed, EphB1-Fc administration, which competes with the endogenous receptor for ephrinB2 binding and prevents behavioral allodynia and hyperalgesia in the carrageenan model of inflammation, also inhibited NR2B phosphorylation in this model.
EphB1 Binding (binding) of associated with hyperalgesia, inflammation and allodynia
11) Confidence 0.30 Published 2008 Journal Neuroscience Section Abstract Doc Link PMC2568875 Disease Relevance 0.68 Pain Relevance 0.72
The aim of this study was to examine possible interactions of ERK and calcineurin in cardioprotection afforded by delta-opioid receptor stimulation.
ERK Binding (interactions) of associated with opioid receptor
12) Confidence 0.18 Published 2006 Journal Basic Res. Cardiol. Section Abstract Doc Link 16619106 Disease Relevance 0.31 Pain Relevance 0.30
On the other hand, estrogens were shown to limit neuronal damage and death, possibly by signaling through PI3K, PKC, ERK or glycogen synthase kinase 3-?
ERK Binding (signaling) of in neuronal associated with death
13) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.39 Pain Relevance 0.40
De novo MEK/ERK-dependent transcription is important for the BDNF-regulated structural plasticity of striatal neurons
ERK Binding (novo) of in neurons
14) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0.09 Pain Relevance 0
In hippocampal neurons, for example, an interaction of ERK and mTOR in increasing the translational capacity has recently been demonstrated after LTP-inducing stimulation and activation of neuromodulatory transmitter receptors (Gelinas et al. 2007; Tsokas et al. 2007), and a dopaminergic stimulation of rapamycin-sensitive local protein synthesis has been implicated in the activation of previously silent synapses (Smith et al. 2005).
ERK Binding (interaction) of in synapses associated with long-term potentiation
15) Confidence 0.05 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567422 Disease Relevance 0 Pain Relevance 0.08

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