INT126848

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Context Info
Confidence 0.50
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 30
Total Number 47
Disease Relevance 15.94
Pain Relevance 8.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) Golgi apparatus (Mapk1)
protein complex (Mapk1) microtubule organizing center (Mapk1) cytoplasm (Mapk1)
Anatomy Link Frequency
neurons 14
thoracic aorta 7
kidney cortex 6
IB4 4
astrocytes 4
Mapk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 83 100.00 Very High Very High Very High
Rostral ventrolateral medulla 55 100.00 Very High Very High Very High
Potency 8 100.00 Very High Very High Very High
Peripheral nerve injury 1 99.80 Very High Very High Very High
medulla 163 99.72 Very High Very High Very High
spinal dorsal horn 6 99.20 Very High Very High Very High
Inflammation 141 98.72 Very High Very High Very High
fluoxetine 8 98.58 Very High Very High Very High
Lasting pain 6 98.44 Very High Very High Very High
Spinal cord 7 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 1 99.80 Very High Very High Very High
Spinal Injuries 6 99.64 Very High Very High Very High
Diabetes Mellitus 1056 99.32 Very High Very High Very High
Starvation 36 99.32 Very High Very High Very High
INFLAMMATION 147 98.72 Very High Very High Very High
Frailty 6 98.60 Very High Very High Very High
Pain 254 98.44 Very High Very High Very High
Hypersensitivity 21 98.26 Very High Very High Very High
Hypertrophy 40 98.16 Very High Very High Very High
Erythema 1 97.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that CFA injection caused an area of localized swelling, erythema, hypersensitivity to thermal stimuli, the decreased response time of hind paw licking (HPL), as well as upregulation of c-Fos protein expression and ERK2 phosphorylation in the ipsilateral spinal dorsal horn and the contralateral primary somatosensory area of cortex and the amygdala of rats.
Positive_regulation (upregulation) of Phosphorylation (phosphorylation) of ERK2 in dorsal horn associated with pressure and volume under development, erythema, spinal dorsal horn, hypersensitivity and amygdala
1) Confidence 0.50 Published 2010 Journal Anat Rec (Hoboken) Section Abstract Doc Link 20583264 Disease Relevance 0.77 Pain Relevance 1.26
In contrast, only a slight increase in phosphorylated p38 MAPK was observed.
Positive_regulation (increase) of Phosphorylation (phosphorylated) of p38 MAPK
2) Confidence 0.48 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18520049 Disease Relevance 0.53 Pain Relevance 0.60
RESULTS: L-DOPA treatment caused phosphorylation of ERK1/2 in the dopamine-denervated striatum after acute and chronic administration.
Positive_regulation (caused) of Phosphorylation (phosphorylation) of ERK1/2 in striatum
3) Confidence 0.47 Published 2007 Journal Biol. Psychiatry Section Body Doc Link 17662258 Disease Relevance 0 Pain Relevance 0
-induced phosphorylation of ERK1/2 was decreased (Fig. 3C and 3D, lower panel).
Positive_regulation (induced) of Phosphorylation (phosphorylation) of ERK1/2
4) Confidence 0.44 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0 Pain Relevance 0
We employed inhibitors and activators of protein kinase A (PKA), protein kinase C (PKC), extracellular signal-regulated kinase 1 and 2 (ERK1/2) and calcium/calmodulin-dependent kinase II (CaMKII) to examine whether these kinases individually or in concert mediate the increase in CREB phosphorylation that is evident as early as 2 h after loose ligation of the sciatic nerve.
Positive_regulation (employed) of Phosphorylation (inhibitors) of extracellular signal-regulated kinase 1 and 2 in sciatic nerve associated with kinase c and sciatic nerve
5) Confidence 0.42 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15882794 Disease Relevance 0.20 Pain Relevance 0.41
Application of 10 µM NMDA resulted in a gradual increase in phosphorylation of ERK2; activation was not significant at 5 min of NMDA application (1.11±0.04, p?
Positive_regulation (increase) of Phosphorylation (phosphorylation) of ERK2
6) Confidence 0.42 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0 Pain Relevance 0.09
Western blotting showed about a 4.5-fold increase in phosphorylation of GJA1 at S255, a MAPK1 site, after exposure to 100 microM 2,2'-DCB compared to untreated and solvent controls.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of MAPK1
7) Confidence 0.41 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 16000550 Disease Relevance 0.21 Pain Relevance 0.27
Cells treated with 2,2'-DCB increased phosphorylated MAPK1, implicating the increase of activation of MAPK1.
Positive_regulation (increased) of Phosphorylation (hosphorylated ) of MAPK1
8) Confidence 0.41 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 16000550 Disease Relevance 0.22 Pain Relevance 0.29
Interestingly, phosphorylated ERK1/2 (pERK1/2) at Thr202 and Tyr204 in RVLM was significantly and preferentially augmented during the pro-life phase (fig. 2), of which returned to baseline during the pro-death phase.
Positive_regulation (augmented) of Phosphorylation (phosphorylated) of ERK1/2 associated with rostral ventrolateral medulla and death
9) Confidence 0.40 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.71 Pain Relevance 0.35
When expressed via an inducible promoter in human embryonic kidney 293 cells, the rat Mas-related gene D (rMrgD) receptor responded to beta-alanine but not L-alanine by elevating intracellular [Ca(2+)], stimulating phosphorylation of the mitogenactivated protein kinases known as extracellular signal-regulated kinase (ERK) 1 and ERK2 and translocating from the plasma membrane to punctate intracellular vesicles.
Positive_regulation (stimulating) of Phosphorylation (phosphorylation) of ERK2 in vesicles
10) Confidence 0.33 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16282220 Disease Relevance 0.08 Pain Relevance 0.03
These interactions increased the potency of beta-alanine to phosphorylate ERK1 and ERK2 as well as maintaining the capacity of beta-alanine to elevate intracellular [Ca(2+)], which was reduced in magnitude and slowed in response with increasing times of expression of rMrgD in isolation.
Positive_regulation (increased) of Phosphorylation (phosphorylate) of ERK2 associated with potency
11) Confidence 0.33 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16282220 Disease Relevance 0.15 Pain Relevance 0.10
Application of 10 µM NMDA resulted in a gradual increase in phosphorylation of ERK2; activation was not significant at 5 min of NMDA application (1.11±0.04, p?
Positive_regulation (increase) of Phosphorylation (phosphorylation) of ERK2
12) Confidence 0.30 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0 Pain Relevance 0.09
A gradual increase in P-Erk2 and P-JNK phosphorylation, subsequent to activation of MEK1/2 and MKK4, may have been obscured by the fact that animals were sacrificed immediately after termination of the swim.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of Erk2
13) Confidence 0.29 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.16 Pain Relevance 0.10
The data obtained in the present study demonstrate that progression of diabetes from 14-days to 28-days caused a factorial increase in p38-MAPK phosphorylation along with NOS upregulation in kidney cortex and thoracic aorta.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of p38-MAPK in kidney cortex associated with diabetes mellitus
14) Confidence 0.18 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.13 Pain Relevance 0
Expression of phosphorylated p38-MAPK was significantly increased in kidney cortex obtained from 28-days diabetes group as compared to 14-days diabetes and control groups.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of p38-MAPK in kidney cortex associated with diabetes mellitus
15) Confidence 0.17 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.20 Pain Relevance 0.16
Therefore, the specific aims of the study are to characterize the progression of STZ-induced renal and vascular dysfunction at 14- and 28-days; and to examine if the progression of STZ-induced diabetes would alter the biosynthesis and activation of ET-1, NO and the phosphorylation of p38-MAPK and ERK1/2 in thoracic aorta, kidney cortex and kidney medulla.


Positive_regulation (activation) of Phosphorylation (phosphorylation) of ERK1/2 in thoracic aorta associated with medulla and diabetes mellitus
16) Confidence 0.17 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.67 Pain Relevance 0.08
Total p38-MAPK and phosphorylated p38-MAPK protein expressions in thoracic aorta were significantly elevated in 14-days and 28-days diabetes groups as compared to control group (Fig 6A1–A3).
Positive_regulation (elevated) of Phosphorylation (phosphorylated) of p38-MAPK in thoracic aorta associated with diabetes mellitus
17) Confidence 0.17 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.26 Pain Relevance 0.16
In the present study, we observed that ERK1/2 precedes p38-MAPK phosphorylation depending upon the progression of diabetes from 14-days to 28-days.
Positive_regulation (depending) of Phosphorylation (phosphorylation) of ERK1/2 associated with diabetes mellitus
18) Confidence 0.17 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.85 Pain Relevance 0.05
Chronic treatment of astrocytes with therapeutically relevant fluoxetine concentrations enhances cPLA2 expression secondary to 5-HT2B-induced, transactivation-mediated ERK1/2 phosphorylation.
Positive_regulation (transactivation) of Phosphorylation (phosphorylation) of ERK1/2 in astrocytes associated with fluoxetine
19) Confidence 0.13 Published 2009 Journal Psychopharmacology (Berl.) Section Title Doc Link 19662385 Disease Relevance 0 Pain Relevance 0.43
Chronic treatment of astrocytes with therapeutically relevant fluoxetine concentrations enhances cPLA2 expression secondary to 5-HT2B-induced, transactivation-mediated ERK1/2 phosphorylation.
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of ERK1/2 in astrocytes associated with fluoxetine
20) Confidence 0.13 Published 2009 Journal Psychopharmacology (Berl.) Section Title Doc Link 19662385 Disease Relevance 0 Pain Relevance 0.43

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