INT126849

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.24
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
neurons 2
synapses 2
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 1 97.88 Very High Very High Very High
long-term potentiation 6 97.40 Very High Very High Very High
spinal dorsal horn 4 91.92 High High
Kinase C 5 90.28 High High
dopamine receptor 20 66.44 Quite High
Sciatic nerve 1 65.28 Quite High
Peripheral nerve injury 1 50.24 Quite High
Lasting pain 1 48.88 Quite Low
agonist 24 44.64 Quite Low
Dopamine 26 44.32 Quite Low
Disease Link Frequency Relevance Heat
Injury 1 96.40 Very High Very High Very High
Aids-related Complex 6 92.36 High High
Nervous System Injury 1 50.24 Quite High
Pain 1 48.88 Quite Low
Shock 10 18.32 Low Low
Disease 7 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Each kinase inhibitor significantly attenuated the ligation-associated activation of ERK1/2 as well.
Positive_regulation (activation) of ERK Binding (ligation-associated) of
1) Confidence 0.49 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15882794 Disease Relevance 0.15 Pain Relevance 0.41
De novo MEK/ERK-dependent transcription is important for the BDNF-regulated structural plasticity of striatal neurons
Positive_regulation (important) of ERK Binding (novo) of in neurons
2) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0.09 Pain Relevance 0
In hippocampal neurons, for example, an interaction of ERK and mTOR in increasing the translational capacity has recently been demonstrated after LTP-inducing stimulation and activation of neuromodulatory transmitter receptors (Gelinas et al. 2007; Tsokas et al. 2007), and a dopaminergic stimulation of rapamycin-sensitive local protein synthesis has been implicated in the activation of previously silent synapses (Smith et al. 2005).
Positive_regulation (increasing) of ERK Binding (interaction) of in synapses associated with long-term potentiation
3) Confidence 0.06 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567422 Disease Relevance 0 Pain Relevance 0.08

General Comments

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