INT126852

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkaca, Creb1) mitochondrion (Prkaca, Creb1) nucleus (Prkaca, Creb1)
Golgi apparatus (Prkaca) DNA binding (Creb1) protein complex (Prkaca)
Anatomy Link Frequency
dorsal horn 1
Prkaca (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 5 100.00 Very High Very High Very High
spinal dorsal horn 4 98.98 Very High Very High Very High
Dorsal horn 1 89.60 High High
Sciatic nerve 1 57.00 Quite High
Peripheral nerve injury 1 41.96 Quite Low
Lasting pain 1 40.60 Quite Low
Disease Link Frequency Relevance Heat
Injury 1 88.12 High High
Nervous System Injury 1 41.96 Quite Low
Pain 1 40.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that early, sciatic ligation-elicited phosphorylation of CREB in the spinal dorsal horn is mediated by multiple kinase pathways, and that PKA, PKC and CaMKII activate CREB at least in part by way of the ERK pathway.
PKA Positive_regulation (activate) of CREB in dorsal horn associated with kinase c and spinal dorsal horn
1) Confidence 0.27 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15882794 Disease Relevance 0.09 Pain Relevance 0.32

General Comments

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