INT126864

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.58
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Csk) plasma membrane (Csk) cytoplasm (Csk)
Anatomy Link Frequency
dorsal root ganglia 1
Csk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 8 92.32 High High
withdrawal 1 91.76 High High
IPN 1 55.04 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 1 93.24 High High
INFLAMMATION 5 92.32 High High
Pressure And Volume Under Development 1 90.60 High High
Inflammatory Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical assays performed in ipsilateral L4/L5 dorsal root ganglia obtained following FCA/wild-type ODN treatment showed: (1) an inhibition of the activity of c-Src kinase, a member of the non-receptor tyrosine kinase super family, (2) a decreased level of p65 NF(kappa)B subunit, and (3) an inhibition of cyclooxygenase-2 (COX-2) protein expression, a major pro-inflammatory enzyme transcriptionally controlled by NF(kappa)B.
Negative_regulation (inhibition) of Src kinase in dorsal root ganglia associated with inflammation
1) Confidence 0.12 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15882800 Disease Relevance 0.58 Pain Relevance 0.30

General Comments

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