INT126896

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Context Info
Confidence 0.13
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0.99
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (SP1) nucleus (SP1) intracellular (SP1)
DNA binding (SP1) transcription factor binding (SP1) cytoplasm (SP1)
Anatomy Link Frequency
colon 4
SP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 6 99.28 Very High Very High Very High
COX2 4 99.24 Very High Very High Very High
cINOD 2 92.80 High High
Disease Link Frequency Relevance Heat
Colon Cancer 12 99.80 Very High Very High Very High
INFLAMMATION 2 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the antiangiogenic activity of COX-2 inhibitors in colon cancer cells is linked to activation of proteasome-dependent degradation of Sp1 and Sp4 proteins.
Positive_regulation (activation) of Protein_catabolism (degradation) of Sp1 in colon associated with colon cancer and cox-2 inhibitor
1) Confidence 0.13 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15883203 Disease Relevance 0.50 Pain Relevance 0.18
Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins.
Positive_regulation (enhanced) of Protein_catabolism (degradation) of Sp1 in colon associated with colon cancer and cox2
2) Confidence 0.13 Published 2005 Journal Mol. Pharmacol. Section Title Doc Link 15883203 Disease Relevance 0.49 Pain Relevance 0.26

General Comments

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