INT126899

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.53
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (SP1) nucleus (SP1) intracellular (SP1)
DNA binding (SP1) transcription factor binding (SP1) cytoplasm (SP1)
Anatomy Link Frequency
proximal 2
SW-480 1
SP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 6 99.84 Very High Very High Very High
mu opioid receptor 7 97.00 Very High Very High Very High
Central nervous system 4 88.88 High High
cINOD 23 63.40 Quite High
Morphine 2 58.20 Quite High
COX2 2 56.16 Quite High
narcan 1 52.12 Quite High
cytokine 16 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 5 99.36 Very High Very High Very High
Apoptosis 38 98.84 Very High Very High Very High
Colon Cancer 10 98.52 Very High Very High Very High
Cancer 23 97.80 Very High Very High Very High
Adhesions 5 96.36 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 141 95.36 Very High Very High Very High
Familial Adenomatous Polyposis 4 89.88 High High
Death 9 83.84 Quite High
INFLAMMATION 9 63.16 Quite High
Immunotherapy Of Cancer 1 58.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of transcription factors Sp1 and YY1 in proximal promoter region in initiation of transcription of the mu opioid receptor gene in human lymphocytes.
Regulation (role) of Sp1 in proximal associated with mu opioid receptor
1) Confidence 0.43 Published 2008 Journal J. Cell. Biochem. Section Title Doc Link 17990281 Disease Relevance 0 Pain Relevance 0.35
The repressor activity of Sp1 and Sp3 is regulated by the expression of CK2 [77].
Regulation (regulated) of Sp1
2) Confidence 0.15 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.34 Pain Relevance 0
Thus, Sp1 can be another possible molecular target for tolfenamic acid-induced apoptosis.
Spec (possible) Regulation (target) of Sp1 associated with apoptosis
3) Confidence 0.13 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901767 Disease Relevance 1.40 Pain Relevance 0
COX-2 inhibitors do not affect Sp1 or Sp4 mRNA levels in SW-480 cells; however, decreased expression of both proteins was accompanied by increased protein ubiquitination and inhibited by the proteasome inhibitor gliotoxin.
Neg (not) Regulation (affect) of Sp1 in SW-480 associated with cox-2 inhibitor
4) Confidence 0.11 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15883203 Disease Relevance 0.46 Pain Relevance 0.22
At the level of transcriptional regulation, changes in the levels of cellular binding of the transcription factors Sp-1 and AP-2 to their cognate response DNA sequences contained within the proximal promoter region of the gene of a cartilage matrix component, aggrecan, are indeed the targets of TGF-?
Regulation (regulation) of Sp-1 in proximal
5) Confidence 0.03 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.33 Pain Relevance 0

General Comments

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