INT126906

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Context Info
Confidence 0.21
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 9.20
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CD86 4
blood 2
monocyte 2
brain 2
NK cells 2
H2 (Mus musculus)
Pain Link Frequency Relevance Heat
drug abuse 12 99.00 Very High Very High Very High
cytokine 101 98.36 Very High Very High Very High
Serotonin 92 97.96 Very High Very High Very High
Central nervous system 38 96.92 Very High Very High Very High
Peripheral nervous system 5 95.48 Very High Very High Very High
Neuritis 29 85.24 High High
Inflammation 58 81.36 Quite High
Inflammatory mediators 2 73.36 Quite High
Hippocampus 10 70.60 Quite High
opiate 3 64.72 Quite High
Disease Link Frequency Relevance Heat
Infection 275 99.80 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 33 99.60 Very High Very High Very High
Influenza Virus Infection 7 99.56 Very High Very High Very High
Viral Meningitis 24 99.32 Very High Very High Very High
Drug Dependence 12 99.00 Very High Very High Very High
Adhesions 8 98.72 Very High Very High Very High
Severe Combined Immunodeficiency 1 98.40 Very High Very High Very High
Targeted Disruption 33 91.64 High High
Neurocysticercosis 30 91.60 High High
Viral Infection 16 85.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As for the concentration of H2, it was reported that H2 dissolved in arterial blood was increased by the inhalation of H2 in proportion to the concentration inhaled, from 0 to 4%, together with O2 and N2O; the amount of H2 dissolved in venous blood was less than that in artery blood, suggesting that H2 had been incorporated into tissues [1].
Positive_regulation (increased) of Gene_expression (inhalation) of H2 in blood
1) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.25 Pain Relevance 0.15
The increased MHC-II and CD40 expression on SCs was accompanied by lower levels of intracellular IL-6 production within SCs of apoE deficiency, which is confirmed by the neutralization with anti IL-6 antibody.
Positive_regulation (increased) of Gene_expression (expression) of MHC-II in SCs
2) Confidence 0.16 Published 2007 Journal Glia Section Abstract Doc Link 17357152 Disease Relevance 0.90 Pain Relevance 0.41
We further suggest that exercise induces a microglial phenotype shift from a macrophagic phenotype to an antigen presenting phenotype, expressing CD11c and MHC II.
Positive_regulation (induces) of Gene_expression (expressing) of MHC II
3) Confidence 0.15 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2329612 Disease Relevance 0.76 Pain Relevance 0.05
ApoE-deficient mice were observed to reduce the expression of intracellular IL-6 accompanied with higher levels of MHC II and CD 40 expression on SCs.
Positive_regulation (levels) of Gene_expression (expression) of MHC II
4) Confidence 0.11 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.56 Pain Relevance 0.51
Amaya lparraguirre reported that although both influenza virus and CpG led to increased expression levels of costimulatory molecules on PDCs, including CD40 and CD86 as well as MHC II, an exception was CD80, which was expressed to the lower extend under the CpG stimuli than the influenza virus stimuli [38].
Positive_regulation (increased) of Gene_expression (expression) of MHC II in CD86 associated with influenza virus infection
5) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.33 Pain Relevance 0
Specifically, increased 5HT2A activity causes decreased MHC II production,[107] and decreased selection against self-reactive helper T cells (TH1) [108].
Positive_regulation (causes) of Gene_expression (production) of MHC II in helper T cells
6) Confidence 0.07 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.51 Pain Relevance 0.18
Later the large granular lymphocytes (NK cells) were recognised as important producers by the fact that Ia-antigen (MHC-II) expression on mouse macrophages could be induced by Listeria monocytogenes infection in SCID mice lacking T cells [194-196].
Positive_regulation (induced) of Gene_expression (expression) of MHC-II in NK cells associated with severe combined immunodeficiency and infection
7) Confidence 0.05 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.71 Pain Relevance 0
Likewise, dendritic cells stimulated with helminth components show limited upregulation of CD80, CD86 and MHC-II expression in comparison to the expression induced by bacterial antigens [37].
Positive_regulation (upregulation) of Gene_expression (expression) of MHC-II in CD86
8) Confidence 0.04 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.67 Pain Relevance 0.09
Finally the increased expression of MHC II and CD68 detected in drug abusers with HIVE compared to nondrug abusers with HIVE suggests that the combination of drug abuse and HIV infection has a greater deleterious effect on the brain than either individual insult on its own.
Positive_regulation (increased) of Gene_expression (expression) of MHC II in brain associated with drug abuse, acquired immune deficiency syndrome or hiv infection, viral meningitis and infection
9) Confidence 0.03 Published 2005 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 15885069 Disease Relevance 1.21 Pain Relevance 0.11
We find increased expression of MHC II and CD16 in response to drug abuse.
Positive_regulation (increased) of Gene_expression (expression) of MHC II associated with drug abuse
10) Confidence 0.02 Published 2005 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 15885069 Disease Relevance 1.42 Pain Relevance 0.22
We find no evidence of microglial proliferation in any of our study groups, including HIVE, although HIV infection leads to increased expression of CD16, CD68 and MHC II.
Positive_regulation (increased) of Gene_expression (expression) of MHC II associated with acquired immune deficiency syndrome or hiv infection, viral meningitis and infection
11) Confidence 0.02 Published 2005 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 15885069 Disease Relevance 1.30 Pain Relevance 0.16
surface, by inducing macrophage major histocompatibility class II (MHC-II)

& LeuM3 cell surface expression and by accelerating monocyte

Positive_regulation (inducing) of Gene_expression (expression) of MHC-II in monocyte
12) Confidence 0.02 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.57 Pain Relevance 0.04

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