INT12691

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Context Info
Confidence 0.24
First Reported 1982
Last Reported 1991
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.24
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell-cell signaling (SST, POMC) extracellular space (SST, POMC) extracellular region (SST, POMC)
small molecule metabolic process (POMC) cytoplasm (POMC) generation of precursor metabolites and energy (POMC)
Anatomy Link Frequency
pituitary 4
SST (Homo sapiens)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 14 100.00 Very High Very High Very High
Neuropeptide 8 92.16 High High
substance P 2 80.80 Quite High
Enkephalin 4 79.04 Quite High
Opioid 2 58.04 Quite High
Disease Link Frequency Relevance Heat
Syndrome 6 99.12 Very High Very High Very High
Adenoma 4 99.00 Very High Very High Very High
Pituitary Cancer 6 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, this study indicates that, in man, somatostatin selectively inhibits the CRF-induced secretion of beta-EP, but not that of ACTH and beta-LPH, by an action that may be exerted at pituitary or extrapituitary level.
somatostatin Negative_regulation (inhibits) of Localization (secretion) of ACTH in pituitary associated with somatostatin
1) Confidence 0.24 Published 1991 Journal Horm. Metab. Res. Section Abstract Doc Link 1651895 Disease Relevance 0 Pain Relevance 0.17
In conclusion, this study indicates that, in man, somatostatin selectively inhibits the CRF-induced secretion of beta-EP, but not that of ACTH and beta-LPH, by an action that may be exerted at pituitary or extrapituitary level.
somatostatin Negative_regulation (inhibits) of Localization (secretion) of beta-LPH in pituitary associated with somatostatin
2) Confidence 0.24 Published 1991 Journal Horm. Metab. Res. Section Abstract Doc Link 1651895 Disease Relevance 0 Pain Relevance 0.17
Results showed that somatostatin-14 and somatostatin-28 suppressed the secretion of POMC-derived peptides by the adenoma and that somatostatin-28 was as potent as somatostatin-14.
somatostatin-28 Negative_regulation (suppressed) of Localization (secretion) of POMC associated with adenoma and somatostatin
3) Confidence 0.08 Published 1982 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6126487 Disease Relevance 0.62 Pain Relevance 0.55
Results showed that somatostatin-14 and somatostatin-28 suppressed the secretion of POMC-derived peptides by the adenoma and that somatostatin-28 was as potent as somatostatin-14.
somatostatin-14 Negative_regulation (suppressed) of Localization (secretion) of POMC associated with adenoma and somatostatin
4) Confidence 0.08 Published 1982 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6126487 Disease Relevance 0.62 Pain Relevance 0.55

General Comments

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