INT126910

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.81
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx3) Golgi apparatus (P2rx3)
Anatomy Link Frequency
neurons 2
spinal cord dorsal horn 2
P2rx3 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 46 99.78 Very High Very High Very High
intrathecal 10 99.44 Very High Very High Very High
Spinal cord 6 98.92 Very High Very High Very High
Dorsal horn 1 98.44 Very High Very High Very High
Lasting pain 2 97.40 Very High Very High Very High
Pain 38 96.84 Very High Very High Very High
qutenza 5 95.36 Very High Very High Very High
agonist 10 94.96 High High
substance P 9 91.68 High High
Potency 3 86.40 High High
Disease Link Frequency Relevance Heat
Cancer 6 98.64 Very High Very High Very High
Pain 35 97.40 Very High Very High Very High
Neuropathic Pain 48 86.36 High High
Cancer Pain 2 75.00 Quite High
Neurological Disease 1 73.80 Quite High
Hyperalgesia 8 73.24 Quite High
Fibrosarcoma 1 69.84 Quite High
Diabetes Mellitus 44 63.00 Quite High
Diabetic Neuropathy 36 62.24 Quite High
Ganglion Cysts 11 51.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies demonstrate increased expression of P2X3 receptors on CGRP-ir ENFs during tumor growth and suggest a role for ATP in cancer-related pain.
Positive_regulation (increased) of Gene_expression (expression) of P2X3 associated with pain and cancer
1) Confidence 0.62 Published 2005 Journal Brain Res. Section Abstract Doc Link 15885218 Disease Relevance 0.81 Pain Relevance 0.30
Thus, our data indicate a major gain of function of P2X3 receptors without their concomitant overexpression at the plasma membrane or a larger number of P2X3 receptor expressing neurons.
Positive_regulation (overexpression) of Gene_expression (expressing) of P2X3 in neurons
2) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.27 Pain Relevance 0.50
According to Ramer and Bradbury, intrathecal injection of NGF treatment induces more extensive expression of the P2X3 receptor than GDNF in both DRG and spinal cord dorsal horn, and leads to chronic pain [35].
Positive_regulation (induces) of Gene_expression (expression) of P2X3 receptor in spinal cord dorsal horn associated with nerve growth factor, lasting pain, dorsal horn, spinal cord and intrathecal
3) Confidence 0.16 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.72 Pain Relevance 1.28

General Comments

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