INT126943

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Context Info
Confidence 0.00
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.69
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pkd1, ZACN) Golgi apparatus (Pkd1) nucleus (Pkd1)
cilium (Pkd1)
Anatomy Link Frequency
epithelial cells 1
Pkd1 (Mus musculus)
ZACN (Homo sapiens)
Pain Link Frequency Relevance Heat
Mechanosensation 1 77.00 Quite High
TRP channel 1 73.12 Quite High
Transformation-sensitive protein p120 1 66.68 Quite High
Disease Link Frequency Relevance Heat
Autosomal Dominant Polycystic Kidney 4 99.92 Very High Very High Very High
Cyst 1 90.84 High High
Renal Disease 2 86.04 High High
Disease 1 84.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PKD1 and PKD2 are thought to function together as part of a multiprotein receptor/ion-channel complex or independently and may be involved in transducing Ca(2+)-dependent mechanosensitive signals in response to cilia bending in renal epithelial cells and endodermally derived cells.
PKD1 Binding (complex) of receptor/ion-channel in epithelial cells
1) Confidence 0.00 Published 2005 Journal Pflugers Arch. Section Abstract Doc Link 15889307 Disease Relevance 0.69 Pain Relevance 0.14

General Comments

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