INT126944

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Context Info
Confidence 0.08
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.09
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cilium (PKD2, Pkd1) plasma membrane (PKD2, Pkd1) Golgi apparatus (Pkd1)
endoplasmic reticulum (PKD2) transmembrane transport (PKD2) cytoplasm (PKD2)
Anatomy Link Frequency
epithelial cells 1
PKD2 (Homo sapiens)
Pkd1 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 2 100.00 Very High Very High Very High
Mechanosensation 1 77.00 Quite High
Transformation-sensitive protein p120 1 66.68 Quite High
fibrosis 2 43.64 Quite Low
imagery 27 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autosomal Dominant Polycystic Kidney 115 99.92 Very High Very High Very High
Cyst 26 90.84 High High
Renal Disease 12 86.04 High High
Disease 32 84.12 Quite High
Congenital Anomalies 6 75.60 Quite High
Apoptosis 2 72.64 Quite High
Death 3 67.36 Quite High
Polycystic Kidney Disease 12 63.92 Quite High
Chronic Renal Failure 26 59.08 Quite High
Syndrome 15 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PKD1 and PKD2 are thought to function together as part of a multiprotein receptor/ion-channel complex or independently and may be involved in transducing Ca(2+)-dependent mechanosensitive signals in response to cilia bending in renal epithelial cells and endodermally derived cells.
PKD2 Binding (complex) of PKD1 in epithelial cells
1) Confidence 0.08 Published 2005 Journal Pflugers Arch. Section Abstract Doc Link 15889307 Disease Relevance 0.69 Pain Relevance 0.14
Polycystin-2 is a member of the calcium-permeable subfamily of transient receptor potential channels and forms a complex with polycystin-1 [17].
Polycystin-2 Binding (forms) of polycystin-1 associated with trp channel
2) Confidence 0.04 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 1.40 Pain Relevance 0.05

General Comments

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