INT126951

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Context Info
Confidence 0.21
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PNOC) extracellular region (PNOC) Golgi apparatus (OPRM1)
endoplasmic reticulum (OPRM1) plasma membrane (OPRM1) signal transducer activity (OPRM1)
PNOC (Homo sapiens)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 5 100.00 Very High Very High Very High
opioid receptor 2 100.00 Very High Very High Very High
Opioid 1 100.00 Very High Very High Very High
Kinase C 3 96.40 Very High Very High Very High
Enkephalin 2 75.00 Quite High
antagonist 1 34.32 Quite Low
agonist 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuroblastoma 1 59.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we investigate the molecular mechanisms by which acute orphanin FQ/nociceptin (OFQ/N), acting through the nociceptin opioid peptide (NOP) receptor, desensitizes the mu-opioid receptor.
nociceptin Positive_regulation (desensitizes) of mu-opioid receptor associated with orphanin, opioid receptor and opioid
1) Confidence 0.21 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15890842 Disease Relevance 0.06 Pain Relevance 0.60

General Comments

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