INT126960

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Context Info
Confidence 0.66
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.06
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ADRBK1) signal transduction (ADRBK1) aging (ADRBK1)
plasma membrane (ADRBK1) cytoplasm (ADRBK1)
ADRBK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 38 99.80 Very High Very High Very High
Kinase C 3 99.24 Very High Very High Very High
Serotonin 10 81.28 Quite High
orphanin 5 75.00 Quite High
Enkephalin 2 75.00 Quite High
opioid receptor 2 75.00 Quite High
antagonist 16 70.08 Quite High
Opioid 1 34.44 Quite Low
spastic colon 12 5.00 Very Low Very Low Very Low
Migraine 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 1 57.52 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

9 5.00 Very Low Very Low Very Low
Migraine Disorders 6 5.00 Very Low Very Low Very Low
Functional Bowel Disorder 5 5.00 Very Low Very Low Very Low
Appetite Loss 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 3 5.00 Very Low Very Low Very Low
Gastroesophageal Reflux Disease 3 5.00 Very Low Very Low Very Low
Constipation 3 5.00 Very Low Very Low Very Low
Cluster Headache 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that OFQ/N binds to NOP receptors and activates protein kinase C, which then increases the ability of GRK2 to phosphorylate the agonist-occupied mu receptor, heterologously regulating homologous mu receptor desensitization.
Phosphorylation (phosphorylate) of GRK2 associated with kinase c and agonist
1) Confidence 0.66 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15890842 Disease Relevance 0.06 Pain Relevance 0.41
Both GRK2 and GRK5 can phosphorylate many GPCRs including 5–HT4 receptor splice variants [10] and GRK2 in particular is crucial for embryonic cardiac development [57].
Phosphorylation (phosphorylate) of GRK2
2) Confidence 0.44 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0 Pain Relevance 0.11

General Comments

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