INT126966

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.93
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL1R1) plasma membrane (IL1R1) intracellular (IL1R1)
signal transducer activity (IL1R1)
Anatomy Link Frequency
liver 1
IL1R 1
IL1R1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 47 99.96 Very High Very High Very High
anakinra 16 99.48 Very High Very High Very High
Fibrositis 54 98.80 Very High Very High Very High
Multiple sclerosis 48 98.20 Very High Very High Very High
cytokine 130 96.48 Very High Very High Very High
Inflammation 157 96.32 Very High Very High Very High
Inflammatory marker 10 94.88 High High
Pain 14 92.68 High High
Neurotransmitter 1 88.56 High High
depression 7 75.00 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 21 99.74 Very High Very High Very High
Fibromyalgia 55 98.80 Very High Very High Very High
Atherosclerosis 36 98.52 Very High Very High Very High
Multiple Sclerosis 57 98.20 Very High Very High Very High
INFLAMMATION 169 96.32 Very High Very High Very High
Hyperplasia 2 96.12 Very High Very High Very High
Bacterial Respiratory Disease 1 94.38 High High
Cancer 8 94.00 High High
Necrosis 11 93.52 High High
Infection 14 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, increased levels of IL-1Ra and IL-6 have been found in the supernatants of cells from FM patients in vitro stimulation and cellular proliferation studies [7].
Positive_regulation (increased) of IL-1Ra associated with fibrositis and hyperplasia
1) Confidence 0.67 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2891797 Disease Relevance 2.24 Pain Relevance 1.05
It seems that treatment of acute and chronic infections and/or inflammations with, for example, antibacterials not metabolized in the liver, and use of medications that decrease proinflammatory cytokine levels (eg, pentoxifylline, a TNF-alpha synthesis inhibitor, directed against TNF-alpha-induced priming of human neutrophils, immunotherapy with IL-4, IL-1 receptor antagonists or factors inducing IL-1ra, dietary supplementation with long-chain n-3 fatty acids, and other antioxidant agents) may perhaps, in some cases, be helpful in the prevention and management of drug-induced hepatotoxicity.
Positive_regulation (inducing) of IL-1ra in liver associated with antagonist, bacterial respiratory disease, hepatotoxicity, infection and cytokine
2) Confidence 0.49 Published 2005 Journal Am J Ther Section Abstract Doc Link 15891270 Disease Relevance 0.58 Pain Relevance 0.31
We do not suggest that I-It solutions are not necessary for reforming our broken medical system, but that they are not sufficient.
Neg (not) Positive_regulation (necessary) of I-It
3) Confidence 0.22 Published 2009 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2733137 Disease Relevance 0.07 Pain Relevance 0
As Buber points out in the quote above, without the establishment of I-Thou relationships, I-It medical technology is disconnected from its purpose and has increased potential for harm.
Positive_regulation (increased) of I-It
4) Confidence 0.22 Published 2009 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2733137 Disease Relevance 0.06 Pain Relevance 0
Among the genes upregulated were IL-1 receptor (IL1R), IL-8 receptor type 2 (IL8RB), IL-11 receptor ?
Positive_regulation (upregulated) of IL1R in IL1R
5) Confidence 0.17 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.41 Pain Relevance 0.59
Pre-clinical studies indicate that IL-1 may be a primary driver of ACS and that the naturally occurring interleukin-1 receptor antagonist (IL-1ra) may inhibit the atherosclerotic process.
Positive_regulation (occurring) of interleukin-1 receptor associated with atherosclerosis and antagonist
6) Confidence 0.14 Published 2008 Journal Trials Section Abstract Doc Link PMC2289802 Disease Relevance 0.85 Pain Relevance 0.34
Three centres in the UK are planning to recruit 186 Non-ST elevation myocardial infarction patients to receive either interleukin-1 receptor antagonist (Anakinra) or matching placebo.
Positive_regulation (receive) of interleukin-1 receptor associated with anakinra, antagonist and myocardial infarction
7) Confidence 0.14 Published 2008 Journal Trials Section Abstract Doc Link PMC2289802 Disease Relevance 0.94 Pain Relevance 0.38
We believe that there are plausible links between IL-1 activation and these markers.
Positive_regulation (activation) of IL-1
8) Confidence 0.13 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 0.77 Pain Relevance 0.16

General Comments

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