INT126967

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Context Info
Confidence 0.79
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.69
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cd34) extracellular region (Cd34) cell motility (Cd34)
cell adhesion (Cd34) plasma membrane (Cd34) transcription factor binding (Cd34)
Anatomy Link Frequency
blood 4
stem cells 2
Cd34 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 11 99.58 Very High Very High Very High
Pain 7 98.90 Very High Very High Very High
ischemia 11 97.00 Very High Very High Very High
Angina 5 81.04 Quite High
headache 4 76.00 Quite High
anesthesia 1 53.56 Quite High
Inflammation 11 50.00 Quite Low
aspirin 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 16 99.72 Very High Very High Very High
Lymphatic System Cancer 5 98.24 Very High Very High Very High
Cv Unclassified Under Development 9 97.00 Very High Very High Very High
Coronary Artery Disease 6 94.20 High High
Apoptosis 3 83.72 Quite High
Adhesions 15 83.12 Quite High
Cv General 3 Under Development 6 81.04 Quite High
Pain 5 78.24 Quite High
Syndrome 3 76.88 Quite High
Headache 3 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mobilization of CD34+ into peripheral blood is attained by either glycosylated (lenograstim) or non-glycosylated recombinant G-CSF (filgrastim). 101 donors, 57 males, median age 42 years (range 16-63) entered this retrospective study.
Localization (Mobilization) of CD34 in blood
1) Confidence 0.79 Published 2005 Journal J Clin Apher Section Abstract Doc Link 15892086 Disease Relevance 0.05 Pain Relevance 0.05
Efficacy of single dose pegfilgrastim in enhancing the mobilization of CD34+ peripheral blood stem cells in aggressive lymphoma patients treated with cisplatin-aracytin-containing regimens.
Localization (mobilization) of CD34 in stem cells associated with pain and lymphatic system cancer
2) Confidence 0.69 Published 2006 Journal Bone Marrow Transplant. Section Title Doc Link 16878144 Disease Relevance 0.55 Pain Relevance 0.16
In both groups, animals transplanted with either human CD34+ or CD34- cells, an increase of human CD68+ cells could be found in the border zone of the lesion (Figure 4B and D (Fig. 4)), while human CD68 could not be found in the contralateral hemisphere or in animals that were not transplanted with human cells (Figure 4C and D (Fig. 4)).
Localization (transplanted) of CD34
3) Confidence 0.67 Published 2005 Journal GMS German Medical Science Section Body Doc Link PMC2703252 Disease Relevance 0.12 Pain Relevance 0
In both groups, animals transplanted with either human CD34+ or CD34- cells, an increase of human CD68+ cells could be found in the border zone of the lesion (Figure 4B and D (Fig. 4)), while human CD68 could not be found in the contralateral hemisphere or in animals that were not transplanted with human cells (Figure 4C and D (Fig. 4)).
Localization (transplanted) of CD34
4) Confidence 0.67 Published 2005 Journal GMS German Medical Science Section Body Doc Link PMC2703252 Disease Relevance 0.12 Pain Relevance 0
Endogenous G-CSF and CD34+ cell mobilization after acute myocardial infarction.
Localization (mobilization) of CD34 associated with myocardial infarction and cytokine
5) Confidence 0.44 Published 2006 Journal Int. J. Cardiol. Section Title Doc Link 16051386 Disease Relevance 0.45 Pain Relevance 0.16
CONCLUSION: In the present study, we have demonstrated for the first time that the spontaneous mobilization of CD34(+) cells into the peripheral blood of patients with AMI is significantly correlated to endogenous G-CSF.
Localization (mobilization) of CD34 in blood
6) Confidence 0.39 Published 2006 Journal Int. J. Cardiol. Section Body Doc Link 16051386 Disease Relevance 0.11 Pain Relevance 0
Granulocyte colony stimulating factor (G-CSF, 5 microg/kg/day) was administered subcutaneously for 5 days for mobilization of CD34(+) cells into the peripheral blood.
Localization (mobilization) of CD34 in blood
7) Confidence 0.30 Published 2006 Journal J Clin Apher Section Abstract Doc Link 16342193 Disease Relevance 0.90 Pain Relevance 0.35
A single bolus of EPO has been shown to increase blood number of EPCs (CD34+/CD45?)
Localization (number) of CD34 in blood
8) Confidence 0.22 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.61 Pain Relevance 0.09
The restricted localization of Sca-1+, CD34+, PW1+ cells to a subset of interstitial cells with caspase activity reveals a critical regulatory role for this population during myogenesis, which may directly contribute to resident muscle stem cells or indirectly regulate stem cells through cell-cell interactions.
Localization (localization) of CD34 in stem cells
9) Confidence 0.08 Published 2008 Journal Stem Cells Section Abstract Doc Link 18258721 Disease Relevance 0.79 Pain Relevance 0.05

General Comments

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