INT126984

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 31
Disease Relevance 20.61
Pain Relevance 6.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il5) extracellular region (Il5)
Anatomy Link Frequency
lymphocytes 2
arm 2
thymocytes 2
epithelium 2
lung 2
Il5 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 469 100.00 Very High Very High Very High
COX2 3 100.00 Very High Very High Very High
Inflammation 818 99.80 Very High Very High Very High
substance P 1 99.76 Very High Very High Very High
spastic colon 8 98.72 Very High Very High Very High
Inflammatory response 30 97.48 Very High Very High Very High
chemokine 108 97.20 Very High Very High Very High
Arthritis 26 94.44 High High
cINOD 18 90.40 High High
Potency 20 87.64 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 811 99.80 Very High Very High Very High
Targeted Disruption 32 99.66 Very High Very High Very High
Eczema 35 99.60 Very High Very High Very High
Eosinophilia 41 99.44 Very High Very High Very High
Asthma 579 99.40 Very High Very High Very High
Rhinitis 65 99.36 Very High Very High Very High
Adhesions 37 98.96 Very High Very High Very High
Parasitic Infection 5 98.82 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

6 98.72 Very High Very High Very High
Disease 441 98.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Eosinophilia, a hallmark of both helminth infections and atopic diseases, is maintained through upregulation of eosinophilopoiesis by means of increased production and effectiveness of Interleukin-5 (IL-5), a major Th2 cytokine.
Positive_regulation (increased) of Gene_expression (production) of Interleukin-5 associated with worm infection, disease, eosinophilia and cytokine
1) Confidence 0.69 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17691935 Disease Relevance 0.83 Pain Relevance 0.23
Eosinophilia, a hallmark of both helminth infections and atopic diseases, is maintained through upregulation of eosinophilopoiesis by means of increased production and effectiveness of Interleukin-5 (IL-5), a major Th2 cytokine.
Positive_regulation (increased) of Gene_expression (production) of IL-5 associated with worm infection, disease, eosinophilia and cytokine
2) Confidence 0.50 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17691935 Disease Relevance 0.83 Pain Relevance 0.23
The time course of ovalbumin-induced production of the bronchoalveolar lavage T-helper 2 cytokines (interleukin-5 and interleukin-4) was also studied.
Positive_regulation (-) of Gene_expression (production) of interleukin-5 associated with cytokine
3) Confidence 0.45 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406499 Disease Relevance 0.59 Pain Relevance 0.30
Similarly, a significant inhibition of allergen-induced interleukin-5 production on day 1 and eosinophilia on day 2 was observed at a dose of 0.3 mg/kg of budesonide in females only.
Positive_regulation (-) of Gene_expression (production) of interleukin-5 associated with eosinophilia
4) Confidence 0.45 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406499 Disease Relevance 0.88 Pain Relevance 0.39
8.2 TCR transgenic mice stimulated with MBP Ac 1-11 peptide in the presence of testosterone resulted in increased production of IL-10 and IL-5 and decreased production of IFN-?
Positive_regulation (resulted) of Gene_expression (production) of IL-5 associated with targeted disruption
5) Confidence 0.43 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.70 Pain Relevance 0.30
8.2 TCR transgenic mice stimulated with MBP Ac 1-11 peptide in the presence of testosterone resulted in increased production of IL-10 and IL-5 and decreased production of IFN-?
Positive_regulation (increased) of Gene_expression (production) of IL-5 associated with targeted disruption
6) Confidence 0.43 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.64 Pain Relevance 0.30
8.2 TCR transgenic mice stimulated with MBP Ac 1-11 peptide in the presence of testosterone resulted in increased production of IL-10 and IL-5 and decreased production of IFN-?
Positive_regulation (with) of Gene_expression (production) of IL-5 associated with targeted disruption
7) Confidence 0.31 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.71 Pain Relevance 0.31
A mathematical model published before was applied [27] and the relative expression ratio was calculated from the real-time PCR efficiencies and the crossing point deviation of an unknown sample versus a control Ct IL-5 represents cycles when IL-5 expression is augmented; Ct Ract represents cycles when R actine expression is augmented (control); Ct IL-5/Ct Ract represents ratio.
Positive_regulation (augmented) of Gene_expression (expression) of IL-5
8) Confidence 0.31 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0 Pain Relevance 0.07
Following an acute ovalbumin challenge, actively sensitised BALB/c mice developed a time-dependent increase in interleukin-4 and interleukin-5 production and inflammatory cell influx into bronchoalveolar lavage fluid.
Positive_regulation (increase) of Gene_expression (production) of interleukin-5 associated with inflammation
9) Confidence 0.30 Published 2004 Journal BMC Pharmacol Section Abstract Doc Link PMC406499 Disease Relevance 0.57 Pain Relevance 0.21
Similarly, a significant inhibition of allergen-induced interleukin-5 production on day 1 and eosinophilia on day 2 was observed at a dose of 0.3 mg/kg of budesonide in females only.
Positive_regulation (induced) of Gene_expression (production) of interleukin-5 associated with eosinophilia
10) Confidence 0.30 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406499 Disease Relevance 0.88 Pain Relevance 0.39
Because IgE levels in BALF are dependent upon IL-4, IL-5, IL-13 and may be considered
Positive_regulation (upon) of Gene_expression (dependent) of IL-5
11) Confidence 0.26 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.28 Pain Relevance 0.13
High

levels of interleukin-4 and interleukin-5 are related to clinical measures of

Positive_regulation (related) of Gene_expression (levels) of interleukin-5
12) Confidence 0.26 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.51 Pain Relevance 0.10
Chronic OVA challenge in WT mice induced a significant increase in lung levels of IL-5 (p < 0.03)(Figure 5A), IL-13 (p < 0.04)(Figure 5B), and eotaxin-1 (p < 0.01)(Figure 5C) compared to WT mice not challenged with OVA.
Positive_regulation (increase) of Gene_expression (levels) of IL-5 in lung
13) Confidence 0.22 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0.10
The expression of IL-4, IL-5, IL-6 and IL-33 were induced in BMMC (Figure 2A) after either stimulation.
Positive_regulation (induced) of Gene_expression (expression) of IL-5
14) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.09
This results in an increased expression of Th2 cytokines, such as IL-4, IL-5 and IL-13.
Positive_regulation (results) of Gene_expression (expression) of IL-5 associated with cytokine
15) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2831838 Disease Relevance 0.51 Pain Relevance 0.13
Experimental parasitic infection of mice bowel resulted in elevated substance P levels and increased expression of cyclooxygenase 2 (COX 2) enzyme, prostaglandin E2, IL-4, IL-5, and IL-13.
Positive_regulation (increased) of Gene_expression (expression) of IL-5 in bowel associated with parasitic infection, cox2 and substance p
16) Confidence 0.14 Published 2005 Journal Med. Hypotheses Section Abstract Doc Link 15893125 Disease Relevance 0.73 Pain Relevance 0.86
In contrast, our second series of experiments showed that DEP-OC, rather than washed DEP, enhanced allergen-related eosinophilic inflammation and proliferation of goblet cells in the airway epithelium, which was paralleled by the enhanced lung expression of eotaxin and interleukin-5.
Positive_regulation (enhanced) of Gene_expression (expression) of interleukin-5 in epithelium associated with rhinitis and inflammation
17) Confidence 0.14 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2127221 Disease Relevance 0.97 Pain Relevance 0.14
The effect may be mediated, at least partly, through the increased local expression of IL-5 and eotaxin and also by the modulated expression of IL-13, MCP-1, IL-6, and RANTES.
Positive_regulation (increased) of Gene_expression (expression) of IL-5
18) Confidence 0.13 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 0.30 Pain Relevance 0.08
In our study, airway inflammation induced by the combined administration of nano particles and antigen were concomitant with the increased protein levels of IL-5.
Positive_regulation (increased) of Gene_expression (levels) of IL-5 associated with inflammation
19) Confidence 0.13 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 0.98 Pain Relevance 0.25
These results provide the first evidence that nano particles can accelerate antigen-related IL-5 expression and subsequent eosinophilic inflammation.
Positive_regulation (accelerate) of Gene_expression (expression) of IL-5 associated with rhinitis and inflammation
20) Confidence 0.13 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 1.01 Pain Relevance 0.28

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