INT126988

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.88
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn3) cytoplasm (Accn3)
Anatomy Link Frequency
DRG 3
neurons 2
Accn3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 8 99.40 Very High Very High Very High
ASIC 18 88.04 High High
nociceptor 15 84.48 Quite High
Pain 11 81.32 Quite High
c fibre 4 69.20 Quite High
Spinal cord 7 20.60 Low Low
ketamine 2 5.00 Very Low Very Low Very Low
qutenza 2 5.00 Very Low Very Low Very Low
Root ganglion neuron 2 5.00 Very Low Very Low Very Low
Thoracotomy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 7 99.40 Very High Very High Very High
Pain 6 81.32 Quite High
Acidosis 4 75.04 Quite High
Nociception 2 72.68 Quite High
Targeted Disruption 4 25.76 Quite Low
Cough 5 5.00 Very Low Very Low Very Low
Ganglion Cysts 4 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These relative proportions might be a slight overestimation of the situation under physiological conditions, since tracer application caused, to some extent, local inflammation, and inflammatory conditions lead to increased ASIC3 transcription in vivo and to an increased number of ASIC3 expressing neurons in vitro [46,47].
Transcription (transcription) of ASIC3 in neurons associated with inflammation
1) Confidence 0.61 Published 2006 Journal Respir Res Section Body Doc Link PMC1524950 Disease Relevance 0.43 Pain Relevance 0.43
ASIC1b transcripts and ASIC3 transcripts were expressed in approximately 10% and 30-35% of the DRG neurons, respectively, and the greater part of each population was located in small-to-medium (30-50 microm)-diameter cells.
Transcription (transcripts) of ASIC3 in DRG
2) Confidence 0.52 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893596 Disease Relevance 0.15 Pain Relevance 0.48
Approximately 30% of the TRPV1-positive neurons expressed ASIC3 transcripts, and the double-labeled neurons were comprised of both small-diameter and medium-diameter cells.
Transcription (expressed) of ASIC3 in neurons
3) Confidence 0.52 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893596 Disease Relevance 0 Pain Relevance 0.14
ASIC1b transcripts and ASIC3 transcripts were expressed in approximately 10% and 30-35% of the DRG neurons, respectively, and the greater part of each population was located in small-to-medium (30-50 microm)-diameter cells.
Transcription (expressed) of ASIC3 in DRG
4) Confidence 0.52 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893596 Disease Relevance 0.15 Pain Relevance 0.47
ASIC1b transcripts and ASIC3 transcripts were expressed in approximately 10% and 30-35% of the DRG neurons, respectively, and the greater part of each population was located in small-to-medium (30-50 microm)-diameter cells.
Transcription (transcripts) of ASIC3 in DRG
5) Confidence 0.52 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893596 Disease Relevance 0.15 Pain Relevance 0.47

General Comments

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