INT126989

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Context Info
Confidence 0.63
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 14
Disease Relevance 5.22
Pain Relevance 6.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn2)
Anatomy Link Frequency
DRG 5
brain 2
chondrocytes 1
BCs 1
hippocampus 1
Accn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 409 100.00 Very High Very High Very High
Hippocampus 43 99.56 Very High Very High Very High
ischemia 378 95.96 Very High Very High Very High
tissue acidosis 14 94.60 High High
Pain 13 93.68 High High
PcTx1 1 91.08 High High
nociceptor 15 90.08 High High
GABAergic 5 90.00 High High
Pyramidal cell 38 88.32 High High
Mechanosensation 1 87.56 High High
Disease Link Frequency Relevance Heat
Nociception 7 98.92 Very High Very High Very High
Cv Unclassified Under Development 364 95.96 Very High Very High Very High
Acidosis 76 94.60 High High
Apoptosis 35 94.08 High High
Pain 13 93.68 High High
Death 63 93.52 High High
Stroke 22 86.84 High High
Necrosis 14 75.76 Quite High
Brain Hemorrhage 21 75.00 Quite High
Injury 32 72.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of ASIC1a mRNA and protein in rat articular chondrocytes was evaluated by reverse transcriptase polymerase chain reaction (RT-PCR) and Western blotting.
Transcription (expression) of ASIC1a in chondrocytes
1) Confidence 0.63 Published 2010 Journal Mol. Cell. Biochem. Section Abstract Doc Link 20179994 Disease Relevance 0.23 Pain Relevance 0.17
Finally, single-cell RT-PCR analysis reveals coexpression of ASIC1a and ASIC2 subunit transcripts in O-LM cells, whereas only ASIC1a subunit transcript is detected in most BCs.
Transcription (detected) of ASIC1a in BCs
2) Confidence 0.17 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20463218 Disease Relevance 0.05 Pain Relevance 0.68
In addition, RT-PCR and western blot analysis showed the preconditioning followed by an ischemic event significantly increased the ASIC 2a mRNA and protein expression when compared to a single ischemic insult (p < 0.01, Figures 3, 4).
Transcription (expression) of ASIC associated with asic
3) Confidence 0.14 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.92 Pain Relevance 0.53
The increase in ASIC 2a mRNA expression in the hippocampal CA1 region in the preconditioned group (PC + Isch) was maximal at 24 h and persisted even at 72 h.


Transcription (expression) of ASIC associated with asic
4) Confidence 0.14 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.59 Pain Relevance 0.58
The time-course of ASIC 2a mRNA expression (as measured by quantitative RT-PCR) in the hippocampal CA1 region for all experimental groups is shown in Figure 3.
Transcription (expression) of ASIC associated with asic
5) Confidence 0.14 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.71 Pain Relevance 0.51
To this end, that ASIC2a can play the role of neuroprotectionwe used western blot and RT-PCR to assess the expression of the ASIC 2a mRNA and protein in normal and ischemic rat brains.
Transcription (expression) of ASIC in brains associated with asic
6) Confidence 0.14 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.72 Pain Relevance 0.62
ASIC1a transcripts were expressed in 20-25% of the DRG neurons, and most of the neurons had small (<30 microm)-diameter cell bodies.
Transcription (transcripts) of ASIC1a in DRG
7) Confidence 0.11 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893596 Disease Relevance 0.16 Pain Relevance 0.51
ASIC1b transcripts and ASIC3 transcripts were expressed in approximately 10% and 30-35% of the DRG neurons, respectively, and the greater part of each population was located in small-to-medium (30-50 microm)-diameter cells.
Transcription (transcripts) of ASIC1b in DRG
8) Confidence 0.11 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893596 Disease Relevance 0.15 Pain Relevance 0.48
ASIC1a transcripts were expressed in 20-25% of the DRG neurons, and most of the neurons had small (<30 microm)-diameter cell bodies.
Transcription (expressed) of ASIC1a in DRG
9) Confidence 0.11 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893596 Disease Relevance 0.16 Pain Relevance 0.51
ASIC1b transcripts and ASIC3 transcripts were expressed in approximately 10% and 30-35% of the DRG neurons, respectively, and the greater part of each population was located in small-to-medium (30-50 microm)-diameter cells.
Transcription (expressed) of ASIC1b in DRG
10) Confidence 0.11 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893596 Disease Relevance 0.15 Pain Relevance 0.48
ASIC1b transcripts and ASIC3 transcripts were expressed in approximately 10% and 30-35% of the DRG neurons, respectively, and the greater part of each population was located in small-to-medium (30-50 microm)-diameter cells.
Transcription (transcripts) of ASIC1b in DRG
11) Confidence 0.11 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893596 Disease Relevance 0.15 Pain Relevance 0.48
In particular, transcripts for ASIC 2a have been detected predominantly in the brain [26,27].
Transcription (transcripts) of ASIC in brain associated with asic
12) Confidence 0.11 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.49 Pain Relevance 0.66
Quantitative real-time RT-PCR with the ABI prism 7500 PCR® Systems (Applied Biosystems, Ltd., USA.) was used to measure mRNA levels for ASIC 2a in the hippocampus.
Transcription (levels) of ASIC in hippocampus associated with hippocampus and asic
13) Confidence 0.11 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.07 Pain Relevance 0.23
RT-PCR and western blot analysis showed that preconditioning prior to an ischemic insult significantly increased ASIC 2a mRNA and protein expression in comparison to the ischemic insult alone (p < 0.01).
Transcription (expression) of ASIC associated with asic
14) Confidence 0.11 Published 2010 Journal International Journal of Molecular Sciences Section Abstract Doc Link PMC2820994 Disease Relevance 0.67 Pain Relevance 0.34

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