INT126990

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (E2F1) nucleoplasm (E2F1) mitochondrion (E2F1)
nucleus (E2F1) DNA binding (E2F1) transcription factor binding (E2F1)
Anatomy Link Frequency
NG108-15 6
E2F1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Delta opioid receptors 3 98.68 Very High Very High Very High
Opioid 3 95.32 Very High Very High Very High
opioid receptor 3 90.08 High High
MU agonist 3 75.00 Quite High
Central nervous system 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Gabapentin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 2 34.88 Quite Low
Cancer 30 8.76 Low Low
Metastasis 6 5.00 Very Low Very Low Very Low
Wound Healing 4 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Foreign-body Reaction 2 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Leukemia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gel shift assays and Western blotting of nuclear extracts from NG108-15 cells revealed increased E2F1 DNA binding activity and higher levels of E2F1 following activation of delta-opioid receptors.
Positive_regulation (increased) of E2F1 Binding (activity) of in NG108-15 associated with delta opioid receptors
1) Confidence 0.58 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893610 Disease Relevance 0 Pain Relevance 0.26
Gel shift assays and Western blotting of nuclear extracts from NG108-15 cells revealed increased E2F1 DNA binding activity and higher levels of E2F1 following activation of delta-opioid receptors.
Positive_regulation (increased) of E2F1 Binding (binding) of in NG108-15 associated with delta opioid receptors
2) Confidence 0.58 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893610 Disease Relevance 0 Pain Relevance 0.26
To further verify E2F-1 binding sites in the promoter of TSP1, on the basis of TSP1-promoter (?
Positive_regulation (verify) of E2F-1 Binding (binding) of
3) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
These observations suggested that the DNA binding activity of E2F1 is required for inducing TSP1 expression.
Positive_regulation (required) of E2F1 Binding (binding) of
4) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
Gel shift assays and Western blotting of nuclear extracts from NG108-15 cells revealed increased E2F1 DNA binding activity and higher levels of E2F1 following activation of delta-opioid receptors.
Positive_regulation (levels) of E2F1 Binding (binding) of in NG108-15 associated with delta opioid receptors
5) Confidence 0.39 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893610 Disease Relevance 0 Pain Relevance 0.26

General Comments

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