INT126993

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 14
Disease Relevance 1.39
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (E2F1) nucleoplasm (E2F1) mitochondrion (E2F1)
nucleus (E2F1) DNA binding (E2F1) transcription factor binding (E2F1)
Anatomy Link Frequency
NG108-15 3
covering 1
H69 1
E2F1 (Homo sapiens)
Pain Link Frequency Relevance Heat
MU agonist 3 99.54 Very High Very High Very High
opioid receptor 3 98.64 Very High Very High Very High
Delta opioid receptors 3 97.96 Very High Very High Very High
Opioid 3 94.92 High High
qutenza 130 94.40 High High
Central nervous system 10 45.80 Quite Low
Gabapentin 10 41.08 Quite Low
Inflammation 11 24.68 Low Low
ischemia 10 22.04 Low Low
cytokine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 192 100.00 Very High Very High Very High
Small Cell Lung Cancer 63 99.66 Very High Very High Very High
Lung Cancer 10 70.72 Quite High
Leukemia 11 68.96 Quite High
Wound Healing 20 49.76 Quite Low
Metastasis 32 45.56 Quite Low
Non-small-cell Lung Cancer 2 40.64 Quite Low
Genomic Instability 1 40.28 Quite Low
Targeted Disruption 10 34.88 Quite Low
Repression 10 33.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further ChIP assays confirmed that E2F-1 could bind the promoter region covering ?
E2F-1 Binding (bind) of in covering
1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
Gel shift assays and Western blotting of nuclear extracts from NG108-15 cells revealed increased E2F1 DNA binding activity and higher levels of E2F1 following activation of delta-opioid receptors.
E2F1 Binding (binding) of in NG108-15 associated with delta opioid receptors
2) Confidence 0.40 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893610 Disease Relevance 0 Pain Relevance 0.26
In this study, we found that E2F-1 could transactivate TSP1 promoter activity and TSP1 promoter region contains potential E2F-1 binding consensus sequences.
E2F-1 Binding (binding) of
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0.23 Pain Relevance 0
In addition, we verified that the DNA binding domain and DNA binding ability of E2F-1 were required for transactivating TSP1 expression.
E2F-1 Binding (binding) of
4) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
In this study, through domain mapping for TSP1 promoter, we identified that the E2F-1 binding consensus sequence located in ?
E2F-1 Binding (binding) of
5) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
To further verify E2F-1 binding sites in the promoter of TSP1, on the basis of TSP1-promoter (?
E2F-1 Binding (binding) of
6) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
Moreover, the roles of E2F-1 in cancer have been well-recognized due to its association with pRB1— a classic tumor suppressor.
E2F-1 Binding (recognized) of associated with cancer
7) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0.37 Pain Relevance 0
These observations suggested that the DNA binding activity of E2F1 is required for inducing TSP1 expression.
E2F1 Binding (binding) of
8) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
After searching for the consensus sequences for E2F-1 binding, we found three potential binding sites presented in TSP1 promoter region between ?
E2F-1 Binding (binding) of
9) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
As a transcription activator, E2F1 can bind DNA cooperatively with DP proteins through the E2 recognition site (5?
E2F1 Binding (bind) of
10) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
Using promoter assays, Northern blot and ChIP (chromatin immunoprecipitation) assays, we identified that E2F-1 could directly transactivate TSP1 expression by binding to its promoter, further expending TSP1's regulatory factors.


E2F-1 Binding (binding) of
11) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0.21 Pain Relevance 0
delta-Opioid agonist induced regulation of E2F1 DNA binding activity in NG108-15 cells.
E2F1 Binding (activity) of in NG108-15 associated with mu agonist
12) Confidence 0.30 Published 2005 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 15893610 Disease Relevance 0 Pain Relevance 0.28
Gel shift assays and Western blotting of nuclear extracts from NG108-15 cells revealed increased E2F1 DNA binding activity and higher levels of E2F1 following activation of delta-opioid receptors.
E2F1 Binding (activity) of in NG108-15 associated with delta opioid receptors
13) Confidence 0.30 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893610 Disease Relevance 0 Pain Relevance 0.26
Control H69 SCLC cells contained E2F1, E2F2 and E2F3 bound to proliferative promoters.
E2F1 Binding (bound) of in H69 associated with small cell lung cancer
14) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.57 Pain Relevance 0.31

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