INT126999

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Context Info
Confidence 0.28
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.37
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cfb) peptidase activity (Cfb) extracellular space (Cfb)
extracellular region (Cfb)
Anatomy Link Frequency
neuronal 2
hepatocytes 2
spinal cord 2
choroid 2
Cfb (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 2 95.92 Very High Very High Very High
Peripheral nervous system 1 95.84 Very High Very High Very High
Inflammation 21 76.64 Quite High
Central nervous system 2 76.12 Quite High
ischemia 3 60.44 Quite High
rheumatoid arthritis 1 59.00 Quite High
alcohol 3 36.24 Quite Low
Pain 1 25.00 Low Low
Nicotine 1 23.72 Low Low
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 16 99.72 Very High Very High Very High
Death 14 98.96 Very High Very High Very High
Brain Injury 38 98.48 Very High Very High Very High
Age-related Macular Degeneration 65 96.80 Very High Very High Very High
Viral Meningitis 1 84.60 Quite High
Targeted Disruption 27 83.28 Quite High
Bacterial Meningitis 1 81.20 Quite High
Nervous System Inflammation 1 76.64 Quite High
Sepsis 1 74.36 Quite High
Injury 11 71.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further understand the functional role of galanin, a mouse overexpressing galanin under the platelet-derived growth factor-B was generated, and high levels of galanin expression were observed in several peripheral tissues and spinal cord.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of factor-B in spinal cord associated with spinal cord
1) Confidence 0.28 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893631 Disease Relevance 0.13 Pain Relevance 0.13
This alternative pathway activation was due to the decrease in CFH levels and increase in CFB levels in the RPE/choroid after laser treatment [94].
Positive_regulation (increase) of Gene_expression (levels) of CFB in choroid
2) Confidence 0.23 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.70 Pain Relevance 0
The lack of factor B leads to reduced neuronal cell death after head injury
Positive_regulation (leads) of Neg (lack) Gene_expression (lack) of factor B in neuronal associated with brain injury and death
3) Confidence 0.16 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1540436 Disease Relevance 1.46 Pain Relevance 0.16
A persistent EGF supplementation in vitro was able only partially rescue the effect of Erk1/2 downregulation in c-Met depleted hepatocytes and restore to some extent the levels of cdc2, Aurora A and B, and Mad2.
Positive_regulation (restore) of Gene_expression (levels) of and B in hepatocytes
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.08 Pain Relevance 0

General Comments

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