INT127

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Context Info
Confidence 0.32
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 5.12
Pain Relevance 6.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ACOT1) lipid metabolic process (ACOT1) cytoplasm (ACOT1)
Anatomy Link Frequency
cerebrospinal fluid 4
reticular formation 1
artery 1
brain 1
thalamus 1
ACOT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 21 99.98 Very High Very High Very High
rapifen 10 99.98 Very High Very High Very High
intrathecal 18 99.84 Very High Very High Very High
epidural 2 99.78 Very High Very High Very High
Pain 26 99.56 Very High Very High Very High
Thalamus 31 99.44 Very High Very High Very High
Central nervous system 12 98.80 Very High Very High Very High
Analgesic 4 96.00 Very High Very High Very High
analgesia 10 95.28 Very High Very High Very High
antinociception 2 94.00 High High
Disease Link Frequency Relevance Heat
Anomia 1 99.84 Very High Very High Very High
Hyperlipoproteinemia Type Ii 6 99.28 Very High Very High Very High
Sleep Disorders 214 99.00 Very High Very High Very High
Pain 16 98.76 Very High Very High Very High
Vomiting 4 98.48 Very High Very High Very High
Aphasia 11 97.32 Very High Very High Very High
Dilated Cardiomyopathy 80 97.16 Very High Very High Very High
Disease 35 95.16 Very High Very High Very High
Poisoning 39 88.76 High High
Language Disorders 3 87.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An active concentrative component of the ACh accumulation in fragments of human term placenta followed kinetics predicted by the Michaelis-Menten equation (Km greater than 15 mM).
Positive_regulation (accumulation) of ACh in placenta
1) Confidence 0.32 Published 1976 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 11531 Disease Relevance 0 Pain Relevance 0.08
These evaluations were performed in response to sequential intracoronary infusions of acetylcholine (ACh, 10?
Positive_regulation (response) of ACh
2) Confidence 0.32 Published 2010 Journal European Heart Journal Section Abstract Doc Link PMC2995954 Disease Relevance 0.43 Pain Relevance 0
In the control group, APV reached its peak value 77 ± 12 s after intracoronary ACh infusion, whereas the NO concentration started to increase 1 min after Ach infusion and reached its peak value after 230 ± 45 s.
Positive_regulation (increase) of Ach
3) Confidence 0.30 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2995954 Disease Relevance 0.33 Pain Relevance 0
In the control group, the diameter at the middle segments of the left anterior descending artery (LAD) and at the proximal and middle segments of the left circumflex artery (LCX) increased significantly in response to Ach; whereas, in the FH group the diameter at the proximal segments of the LAD decreased significantly.
Positive_regulation (increased) of Ach in artery associated with hyperlipoproteinemia type ii
4) Confidence 0.26 Published 1992 Journal J Cardiol Section Abstract Doc Link 1339802 Disease Relevance 0.81 Pain Relevance 0.08
Intravenous alfentanil increased cerebrospinal fluid ACh concentration, and neostigmine enhanced this change.
Positive_regulation (increased) of ACh in cerebrospinal fluid associated with rapifen
5) Confidence 0.20 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9223543 Disease Relevance 0.67 Pain Relevance 1.21
Painful stimulation in sheep increased CSF NE and ACh.
Positive_regulation (increased) of ACh in CSF associated with pain
6) Confidence 0.19 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8623972 Disease Relevance 0.51 Pain Relevance 1.24
IT idazoxan blocked the increase in both NE and ACh.
Positive_regulation (increase) of ACh associated with intrathecal
7) Confidence 0.19 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8623972 Disease Relevance 0.51 Pain Relevance 1.24
We conclude that I.V. administration of four times the dose of clonidine delivered spinally failed to induce a significant increase of ACh in the CSF.
Positive_regulation (increase) of ACh in CSF associated with clonidine
8) Confidence 0.12 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9085961 Disease Relevance 0.06 Pain Relevance 1.11
Epidural clonidine increases acetylcholine (ACh) concentrations in cerebrospinal fluid (CSF) in humans, and experiments in animals support a cholinergic link in spinal alpha2-adrenoceptor-mediated antinociception.
Positive_regulation (increases) of ACh in cerebrospinal fluid associated with antinociception, epidural and clonidine
9) Confidence 0.12 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9085961 Disease Relevance 0.07 Pain Relevance 0.68
For example, Szerb [146] showed in anesthetized cats that stimulation of the reticular formation produced increased cortical ACh and reduced cortical low-frequency activity as measured with EEG.
Positive_regulation (increased) of ACh in reticular formation
10) Confidence 0.07 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.18 Pain Relevance 0.12
The rapid accumulation of ACh in the synaptic junctions of central nervous system and peripheral tissues results in a “cholinergic crisis,” characterized by receptor overstimulation and a range of muscarinic, nicotinic, and central effects [4].
Positive_regulation (accumulation) of ACh in central nervous system associated with central nervous system
11) Confidence 0.06 Published 2010 Journal J Med Toxicol Section Body Doc Link PMC2996541 Disease Relevance 0.24 Pain Relevance 0.09
Second, reduced cortical ACh levels result in the attention-related effects on the amplitude of ERP/ERF components, such as the N1 and P300.
Positive_regulation (result) of ACh
12) Confidence 0.05 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.22 Pain Relevance 0.12
Jacobs et al (1996) have described the beneficial effect of increased brain concentrations of ACh on anomia, correlatively with Tanaka et al (1997) who worked with aphasia patients.
Positive_regulation (increased) of ACh in brain associated with anomia and aphasia
13) Confidence 0.04 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654526 Disease Relevance 0.79 Pain Relevance 0.14
q, EGL-8 phospholipase C and SLO-1 BK channel signaling to modulate ACh neurotransmission and that either reduced or excessive EAT-6 function may lead to increased ACh neurotransmission.
Positive_regulation (increased) of ACh
14) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2860991 Disease Relevance 0.31 Pain Relevance 0.17
That intense activation of either mGluRs or AchRs leads to cyclic paroxysms in isolated thalamic slices is notable because previous in vivo studies have suggested that such activity is generated solely in the neocortex and then spreads to the thalamus [22], [23].
Positive_regulation (activation) of AchRs in thalamus associated with thalamus
15) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637539 Disease Relevance 0 Pain Relevance 0.18
They are responsive to the activation of mGluRs [36] and AchRs (H.R.
Positive_regulation (activation) of AchRs
16) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637539 Disease Relevance 0 Pain Relevance 0.12

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