INT127003

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.02
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.57
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Neu3) plasma membrane (Neu3) carbohydrate metabolic process (Neu3)
Anatomy Link Frequency
spinal cord 1
tubules 1
Neu3 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 5 98.20 Very High Very High Very High
Hyperalgesia 4 95.68 Very High Very High Very High
Spinal cord 4 95.00 High High
Pain 4 92.60 High High
Neurotransmitter 3 82.56 Quite High
Neuronal excitability 1 74.48 Quite High
agonist 24 70.16 Quite High
Inflammation 32 56.64 Quite High
cytokine 41 53.44 Quite High
sodium channel 3 52.16 Quite High
Disease Link Frequency Relevance Heat
Congenital Structural Myopathies 51 99.50 Very High Very High Very High
Injury 71 98.28 Very High Very High Very High
Hyperalgesia 6 95.68 Very High Very High Very High
Frailty 6 94.64 High High
Muscle Weakness 12 94.16 High High
Increased Venous Pressure Under Development 1 86.64 High High
Pressure And Volume Under Development 1 85.56 High High
Nociception 1 80.12 Quite High
Paralysis 3 59.92 Quite High
INFLAMMATION 38 56.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The maxi-K channel contains a consensus caveolin-binding motif (1007YNMLCFGIY1015) in its C-terminus [26], and mutation of phenylalanine within the caveolin-binding motif had previously been shown to disrupt the association between the ganglioside-specific sialidase Neu3 and cav-1 [27].
sialidase Neu3 Binding (association) of
1) Confidence 0.02 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
Using subcellular fractionation of proteins and cross-linking of membrane proteins we have observed that intracolonic capsaicin induced a 50% increase in NKCC1 in the plasma membrane of lumbosacral spinal cord 90 and 180 min after instillation, in parallel with a similar decrease in the cytosolic fraction.
membrane Binding (cross-linking) of in spinal cord associated with qutenza and spinal cord
2) Confidence 0.01 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893647 Disease Relevance 0.34 Pain Relevance 0.93
Moreover, we found no significant differences in membrane receptor ligand binding and activation, and regulation of membrane protein proteolytic activity between 16-week-old DHCR24?
membrane Binding (binding) of
3) Confidence 0.01 Published 2008 Journal Neurochem Res Section Body Doc Link PMC2758381 Disease Relevance 0 Pain Relevance 0
Further, the complement system through formation of the membrane attack complex can potentially mediate IR injury.
membrane Binding (formation) of associated with injury
4) Confidence 0.00 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 0.75 Pain Relevance 0.09
Given this propensity to associate with the plasma membrane, we believe that triadic myotubularin may bind at T-tubules which are the plasma membrane invaginations that, together with terminal cisternae of sarcoplasmic reticulum, form the triads where excitation–contraction coupling occurs (34).
membrane Binding (associate) of in tubules
5) Confidence 0.00 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0 Pain Relevance 0
This sarcolemmal staining demonstrates that myotubularin is certainly capable of membrane association at this site; although it is presently unclear whether biologically significant amounts of endogenous protein are present there.
membrane Binding (association) of
6) Confidence 0.00 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.05 Pain Relevance 0
Recently, mutations in the amphyphisin 2/Bin1 gene in patients with an autosomal recessive form of CNM were shown to alter its membrane tubulation properties and interaction with dynamin 2 (6).
membrane Binding (interaction) of associated with congenital structural myopathies
7) Confidence 0.00 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.43 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox