INT127006

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Context Info
Confidence 0.02
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.43
Pain Relevance 3.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Neu3) plasma membrane (Neu3) carbohydrate metabolic process (Neu3)
Anatomy Link Frequency
plasma 1
spinal cord 1
Neu3 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 276 100.00 Very High Very High Very High
Pain 8 99.52 Very High Very High Very High
qutenza 5 99.38 Very High Very High Very High
Spinal cord 11 99.08 Very High Very High Very High
Morphine 245 93.92 High High
Opioid 70 93.36 High High
Neuronal excitability 1 91.80 High High
Neurotransmitter 1 83.52 Quite High
Antinociceptive 17 81.28 Quite High
agonist 23 80.48 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 6 88.48 High High
Nociception 17 85.76 High High
Urological Neuroanatomy 48 56.32 Quite High
Pain 8 28.48 Quite Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Intractable Pain 4 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low
Drug Dependence 3 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Painful stimuli induce in vivo phosphorylation and membrane mobilization of mouse spinal cord NKCC1 co-transporter.
Phosphorylation (phosphorylation) of membrane in spinal cord associated with pain and spinal cord
1) Confidence 0.02 Published 2005 Journal Neuroscience Section Title Doc Link 15893647 Disease Relevance 0.32 Pain Relevance 0.96
Alternatively, and much more rapidly resensitization may occur through the dephosphorylation and recycling of the internalized MORs to the plasma membrane.
Phosphorylation (dephosphorylation) of membrane in plasma associated with opioid receptor
2) Confidence 0.01 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0 Pain Relevance 0.95
Similar to Akt, membrane-associated nNOS had regulatory phosphorylation at Ser1417 and Ser847, but phosphorylation was almost undetectable for MOR-associated nNOS.
Phosphorylation (phosphorylation) of membrane associated with opioid receptor
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.06 Pain Relevance 0.87
Membrane-associated nNOS was phosphorylated by Akt on Ser1417.
Phosphorylation (phosphorylated) of Membrane
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.05 Pain Relevance 0.83

General Comments

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