INT127007

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.42
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc12a2) plasma membrane (Slc12a2) transmembrane transport (Slc12a2)
Anatomy Link Frequency
spinal cord 2
Slc12a2 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 37 99.98 Very High Very High Very High
Dopamine 34 98.80 Very High Very High Very High
Pain 18 98.76 Very High Very High Very High
intrathecal 30 98.60 Very High Very High Very High
Spinal cord 6 98.44 Very High Very High Very High
Hyperalgesia 19 95.56 Very High Very High Very High
allodynia 80 91.28 High High
GABAergic 6 89.36 High High
Dorsal horn 7 83.92 Quite High
agonist 14 80.68 Quite High
Disease Link Frequency Relevance Heat
Pain 9 98.76 Very High Very High Very High
Hyperalgesia 23 95.56 Very High Very High Very High
Neuropathic Pain 81 91.28 High High
Nociception 4 76.92 Quite High
Targeted Disruption 3 58.92 Quite High
INFLAMMATION 15 50.76 Quite High
Ganglion Cysts 7 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 4 5.00 Very Low Very Low Very Low
Dyspepsia 2 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using subcellular fractionation of proteins and cross-linking of membrane proteins we have observed that intracolonic capsaicin induced a 50% increase in NKCC1 in the plasma membrane of lumbosacral spinal cord 90 and 180 min after instillation, in parallel with a similar decrease in the cytosolic fraction.
Positive_regulation (induced) of Positive_regulation (increase) of NKCC1 in spinal cord associated with qutenza and spinal cord
1) Confidence 0.70 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893647 Disease Relevance 0.38 Pain Relevance 0.98
leading to an increase in NKCC1 activity causing touch evoked pain.
Positive_regulation (leading) of Positive_regulation (increase) of NKCC1 associated with pain
2) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 1.04 Pain Relevance 1.48

General Comments

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