INT127007

Context Info Confidence 0.70 First Reported 2005 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.42 Pain Relevance 2.46

transport (Slc12a2) plasma membrane (Slc12a2) transmembrane transport (Slc12a2)

Anatomy Link Frequency spinal cord 2 Slc12a2 (Mus musculus)

Pain Link Frequency Relevance Heat qutenza 37 99.98 Dopamine 34 98.80 Pain 18 98.76 intrathecal 30 98.60 Spinal cord 6 98.44 Hyperalgesia 19 95.56 allodynia 80 91.28 GABAergic 6 89.36 Dorsal horn 7 83.92 agonist 14 80.68

Disease Link Frequency Relevance Heat Pain 9 98.76 Hyperalgesia 23 95.56 Neuropathic Pain 81 91.28 Nociception 4 76.92 Targeted Disruption 3 58.92 INFLAMMATION 15 50.76 Ganglion Cysts 7 5.00 Peripheral Arterial Disease 4 5.00 Dyspepsia 2 5.00 Overdose 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Using subcellular fractionation of proteins and cross-linking of membrane proteins we have observed that intracolonic capsaicin induced a 50% increase in NKCC1 in the plasma membrane of lumbosacral spinal cord 90 and 180 min after instillation, in parallel with a similar decrease in the cytosolic fraction.

Positive_regulation (induced) of Positive_regulation (increase) of NKCC1 in spinal cord associated with qutenza and spinal cord

1) Confidence 0.70 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893647 Disease Relevance 0.38 Pain Relevance 0.98

leading to an increase in NKCC1 activity causing touch evoked pain.

Positive_regulation (leading) of Positive_regulation (increase) of NKCC1 associated with pain

2) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 1.04 Pain Relevance 1.48

General Comments

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