INT127008

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 4.73
Pain Relevance 7.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc12a2) plasma membrane (Slc12a2) transmembrane transport (Slc12a2)
Anatomy Link Frequency
plasma 1
spinal 1
spinal cord 1
Slc12a2 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 165 99.70 Very High Very High Very High
allodynia 400 99.32 Very High Very High Very High
Pain 74 98.76 Very High Very High Very High
GABAergic 30 98.66 Very High Very High Very High
c fibre 15 98.48 Very High Very High Very High
Spinal cord 14 98.44 Very High Very High Very High
Dopamine 170 98.24 Very High Very High Very High
Dorsal horn 35 98.16 Very High Very High Very High
intrathecal 150 98.04 Very High Very High Very High
agonist 70 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 405 99.32 Very High Very High Very High
Pain 45 98.76 Very High Very High Very High
Hyperalgesia 91 95.00 High High
Targeted Disruption 15 94.20 High High
Ganglion Cysts 35 90.00 High High
INFLAMMATION 75 86.40 High High
Peripheral Arterial Disease 20 82.80 Quite High
Nociception 16 76.36 Quite High
Dyspepsia 10 53.32 Quite High
Injury 5 45.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using subcellular fractionation of proteins and cross-linking of membrane proteins we have observed that intracolonic capsaicin induced a 50% increase in NKCC1 in the plasma membrane of lumbosacral spinal cord 90 and 180 min after instillation, in parallel with a similar decrease in the cytosolic fraction.
Positive_regulation (increase) of NKCC1 in spinal cord associated with qutenza and spinal cord
1) Confidence 0.70 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893647 Disease Relevance 0.38 Pain Relevance 0.98
-fiber input that is GABAergic in nature [13], 2) stroking allodynia following capsaicin injection into the hindpaw is absent in NKCC1 knockout mice [8], 3) spinal application of the NKCC1 blocker BUM inhibits intraplantar capsaicin-evoked, secondary mechanical allodynia in rats [10] and 4) a painful visceral stimulus increases dorsal horn NKCC1 phosphorylation and membrane trafficking [11], both of which are mechanisms known to increase NKCC1 activity and intracellular Cl- concentrations [1,26].
Positive_regulation (increase) of NKCC1 in spinal associated with targeted disruption, pain, qutenza, allodynia, gabaergic and dorsal horn
2) Confidence 0.46 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 0.87 Pain Relevance 1.21
We and others have proposed that GABAergic mechanisms may explain allodynia in inflamed conditions such that NKCC1 activity increases leading to a large depolarization in C-fibers, causing spiking, in response to A?
Positive_regulation (increases) of NKCC1 associated with c fibre, allodynia and gabaergic
3) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 0.90 Pain Relevance 1.32
Moreover, they suggest that endogenous TRPV1 agonists, released in the CNS in painful conditions, might stimulate TRPV1 receptors on primary afferents that, in turn, play a role in increasing NKCC1 activity leading to allodynia.



Positive_regulation (increasing) of NKCC1 associated with pain, allodynia and agonist
4) Confidence 0.43 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC1929059 Disease Relevance 0.80 Pain Relevance 1.38
leading to an increase in NKCC1 activity causing touch evoked pain.
Positive_regulation (increase) of NKCC1 associated with pain
5) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 1.03 Pain Relevance 1.47
Finally, intracolonic capsaicin injection stimulates a rapid and transient increase in spinal phosphorylated NKCC1 and a long lasting increase in trafficking of NKCC1 protein to the plasma membrane [11].
Positive_regulation (increase) of NKCC1 in plasma associated with qutenza
6) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 0.74 Pain Relevance 1.25

General Comments

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