INT127010

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Context Info
Confidence 0.82
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 4.68
Pain Relevance 9.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc12a2) plasma membrane (Slc12a2) transmembrane transport (Slc12a2)
Anatomy Link Frequency
spinal cord 4
plasma 2
spinal 1
visceral 1
Slc12a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 26 100.00 Very High Very High Very High
Dorsal horn 21 99.98 Very High Very High Very High
Pain 62 99.52 Very High Very High Very High
qutenza 121 99.38 Very High Very High Very High
allodynia 240 98.58 Very High Very High Very High
Hyperalgesia 65 98.32 Very High Very High Very High
spinal dorsal horn 9 97.04 Very High Very High Very High
GABAergic 18 93.76 High High
Neuronal excitability 5 93.40 High High
intrathecal 90 88.16 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 243 98.58 Very High Very High Very High
Hyperalgesia 81 98.32 Very High Very High Very High
Targeted Disruption 9 96.02 Very High Very High Very High
Nociception 14 87.36 High High
Pain 27 86.88 High High
INFLAMMATION 45 86.24 High High
Peripheral Arterial Disease 12 75.44 Quite High
Ganglion Cysts 21 66.24 Quite High
Injury 3 54.16 Quite High
Dyspepsia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intracolonic capsaicin also evoked a rapid (10 min) and transient phosphorylation of NKCC1, however, intracolonic saline did not produce significant changes in either NKCC1 trafficking or phosphorylation and none of the treatments induced any alterations of NKCC1 in the thoracic spinal cord.
Phosphorylation (phosphorylation) of NKCC1 in spinal cord associated with qutenza and spinal cord
1) Confidence 0.82 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893647 Disease Relevance 0.35 Pain Relevance 1.10
Painful stimuli induce in vivo phosphorylation and membrane mobilization of mouse spinal cord NKCC1 co-transporter.
Phosphorylation (phosphorylation) of NKCC1 in spinal cord associated with pain and spinal cord
2) Confidence 0.82 Published 2005 Journal Neuroscience Section Title Doc Link 15893647 Disease Relevance 0.33 Pain Relevance 0.98
These results suggest that phosphorylation and recruitment of NKCC1 might play a role in referred mechanical hyperalgesia evoked by a painful visceral stimulus.
Phosphorylation (phosphorylation) of NKCC1 in visceral associated with pain and hyperalgesia
3) Confidence 0.82 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893647 Disease Relevance 0.33 Pain Relevance 1.06
Intracolonic capsaicin also evoked a rapid (10 min) and transient phosphorylation of NKCC1, however, intracolonic saline did not produce significant changes in either NKCC1 trafficking or phosphorylation and none of the treatments induced any alterations of NKCC1 in the thoracic spinal cord.
Phosphorylation (alterations) of NKCC1 in spinal cord associated with qutenza and spinal cord
4) Confidence 0.82 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893647 Disease Relevance 0.34 Pain Relevance 1.09
Finally, intracolonic capsaicin injection stimulates a rapid and transient increase in spinal phosphorylated NKCC1 and a long lasting increase in trafficking of NKCC1 protein to the plasma membrane [11].
Phosphorylation (phosphorylated) of NKCC1 in plasma associated with qutenza
5) Confidence 0.76 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 0.74 Pain Relevance 1.24
-fiber input that is GABAergic in nature [13], 2) stroking allodynia following capsaicin injection into the hindpaw is absent in NKCC1 knockout mice [8], 3) spinal application of the NKCC1 blocker BUM inhibits intraplantar capsaicin-evoked, secondary mechanical allodynia in rats [10] and 4) a painful visceral stimulus increases dorsal horn NKCC1 phosphorylation and membrane trafficking [11], both of which are mechanisms known to increase NKCC1 activity and intracellular Cl- concentrations [1,26].
Phosphorylation (phosphorylation) of NKCC1 in spinal associated with targeted disruption, pain, qutenza, allodynia, gabaergic and dorsal horn
6) Confidence 0.75 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 0.92 Pain Relevance 1.26
Intracolonic capsaicin also evoked a rapid (10 min) and transient phosphorylation of NKCC1, however, intracolonic saline did not produce significant changes in either NKCC1 trafficking or phosphorylation and none of the treatments induced any alterations of NKCC1 in the thoracic spinal cord.
Phosphorylation (phosphorylation) of NKCC1 in spinal cord associated with qutenza and spinal cord
7) Confidence 0.72 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893647 Disease Relevance 0.35 Pain Relevance 1.10
Work from this laboratory has shown previously that an intracolonic capsaicin injection causes a transient increase in NKCC1 phosphorylation and a sustained increase in plasma membrane localization of NKCC1 in the spinal dorsal horn [11].
Phosphorylation (phosphorylation) of NKCC1 in plasma associated with qutenza and spinal dorsal horn
8) Confidence 0.58 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 1.31 Pain Relevance 1.84

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