INT127014

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Context Info
Confidence 0.54
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.11
Pain Relevance 6.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a3)
Anatomy Link Frequency
spinal cord 4
spinal 2
neuronal 2
spinal cord dorsal horn 2
Slc1a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 43 100.00 Very High Very High Very High
Glutamate 38 100.00 Very High Very High Very High
Spinal cord 8 100.00 Very High Very High Very High
dexamethasone 10 99.74 Very High Very High Very High
Antinociceptive 6 98.88 Very High Very High Very High
tolerance 15 98.48 Very High Very High Very High
narcan 6 98.30 Very High Very High Very High
Dorsal horn 2 97.20 Very High Very High Very High
excitatory amino acid 6 96.56 Very High Very High Very High
intrathecal 4 95.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 2 100.00 Very High Very High Very High
Nociception 10 99.80 Very High Very High Very High
Bordatella Infection 2 99.52 Very High Very High Very High
Hyperalgesia 4 93.28 High High
Drug Induced Neurotoxicity 4 92.48 High High
INFLAMMATION 5 89.44 High High
Neuropathic Pain 1 48.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that prevention of spinal glutamate transporter downregulation may regulate the glutamatergic function that has been implicated in the development of morphine tolerance.
Negative_regulation (prevention) of Negative_regulation (downregulation) of glutamate transporter in spinal associated with glutamate, tolerance and morphine
1) Confidence 0.54 Published 2008 Journal Pain Section Abstract Doc Link 18986766 Disease Relevance 0.07 Pain Relevance 1.50
The results showed that MG-132 (5 nmol) given intrathecally blocked morphine-induced glutamate transporter downregulation and the decrease in glutamate uptake activity within the spinal cord dorsal horn.
Negative_regulation (blocked) of Negative_regulation (downregulation) of glutamate transporter in spinal cord dorsal horn associated with glutamate, dorsal horn, spinal cord and morphine
2) Confidence 0.40 Published 2008 Journal Pain Section Abstract Doc Link 18986766 Disease Relevance 0.08 Pain Relevance 1.48
Surprisingly, knock-down of GLAST in the spinal cord using antisense-oligonucleotides decreased glutamate concentrations in cerebrospinal fluid (CSF) and reduced the nociceptive behaviour in the rat formalin assay.
Negative_regulation (decreased) of Negative_regulation (knock-down) of GLAST in spinal cord associated with nociception, targeted disruption, glutamate and spinal cord
3) Confidence 0.37 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16765320 Disease Relevance 0.79 Pain Relevance 0.52
Surprisingly, knock-down of GLAST in the spinal cord using antisense-oligonucleotides decreased glutamate concentrations in cerebrospinal fluid (CSF) and reduced the nociceptive behaviour in the rat formalin assay.
Negative_regulation (reduced) of Negative_regulation (knock-down) of GLAST in spinal cord associated with nociception, targeted disruption, glutamate and spinal cord
4) Confidence 0.37 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16765320 Disease Relevance 0.81 Pain Relevance 0.54
DEX co-infusion prevented the downregulation of glial glutamate transporters (GLAST (Glu-Asp transporter) and GLT-1 (Glu transporter-1)), but not the neuronal GT EAAC1 (excitatory amino acid carrier).
Negative_regulation (prevented) of Negative_regulation (downregulation) of GLAST in neuronal associated with glutamate, dexamethasone and excitatory amino acid
5) Confidence 0.32 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893883 Disease Relevance 0 Pain Relevance 2.01
Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats and prevents glutamate transporter downregulation by suppressing the p38 mitogen-activated protein kinase signaling pathway.
Negative_regulation (prevents) of Negative_regulation (downregulation) of glutamate transporter associated with glutamate, bordatella infection, narcan, antinociceptive and morphine
6) Confidence 0.17 Published 2009 Journal Neuroscience Section Title Doc Link 19409222 Disease Relevance 0.37 Pain Relevance 0.93

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