INT127023

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 20.39
Pain Relevance 6.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcam1) cell adhesion (Vcam1) plasma membrane (Vcam1)
Anatomy Link Frequency
monocyte 10
endothelial cells 6
macrophages 4
skin 2
endothelium 2
Vcam1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 26 99.84 Very High Very High Very High
cytokine 227 99.82 Very High Very High Very High
Inflammation 497 99.70 Very High Very High Very High
aspirin 244 99.70 Very High Very High Very High
licofelone 8 99.54 Very High Very High Very High
Multiple sclerosis 53 99.24 Very High Very High Very High
rheumatoid arthritis 175 97.88 Very High Very High Very High
antagonist 30 96.28 Very High Very High Very High
Central nervous system 21 96.08 Very High Very High Very High
cINOD 49 95.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Atherosclerosis 419 100.00 Very High Very High Very High
Disease 223 100.00 Very High Very High Very High
Adhesions 175 100.00 Very High Very High Very High
Multiple Sclerosis 62 99.96 Very High Very High Very High
Disorder Of Lipid Metabolism 761 99.84 Very High Very High Very High
Rheumatoid Arthritis 222 99.84 Very High Very High Very High
INFLAMMATION 568 99.70 Very High Very High Very High
Apoptosis 36 99.12 Very High Very High Very High
Skin Cancer 11 98.54 Very High Very High Very High
Injury 78 97.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both the neuropeptide-depleted and the DSCG-treated groups, eosinophil infiltration and VCAM-1 expression were suppressed in comparison with the nontreated group.
Negative_regulation (suppressed) of Gene_expression (expression) of VCAM-1 in eosinophil
1) Confidence 0.59 Published 2006 Journal Jpn. J. Ophthalmol. Section Body Doc Link 16767373 Disease Relevance 0 Pain Relevance 0
Treatment with high dose ASA resulted in a decreased VCAM-1 expression below and at the bifurcation (p?
Negative_regulation (decreased) of Gene_expression (expression) of VCAM-1 associated with aspirin
2) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943480 Disease Relevance 0.11 Pain Relevance 0.21
levels are increased during asthma exacerbations, and this change is associated with increased expression of ICAM-1, VCAM-1, and E-selectin.37 In our present study, we found that the expression of VCAM-1 in the lung tissues was significantly decreased in the sTNFR-treatment group compared with the OVA group, suggesting that anti-inflammatory effect of sTNFR may in part be dependent on down-regulation of vascular adhesion molecules and consequent reduction of cell traffic into airway.
Negative_regulation (decreased) of Gene_expression (expression) of VCAM-1 in lung associated with asthma, inflammation and adhesions
3) Confidence 0.42 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 1.18 Pain Relevance 0.27
High dose ASA, but not NCX 4016, inhibited endothelial cell expression of VCAM-1 and thrombomodulin in the carotid arteries at 4 weeks after irradiation; eNOS and ICAM-1 levels were unchanged.
Negative_regulation (inhibited) of Gene_expression (expression) of VCAM-1 in endothelial cell
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943480 Disease Relevance 0.53 Pain Relevance 0.28
In addition to the reduction in percentage of endothelial cells expressing VCAM-1, there was a reduction in the intensity of positive immunostaining below the bifurcation (p?
Negative_regulation (reduction) of Gene_expression (expressing) of VCAM-1 in endothelial cells
5) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943480 Disease Relevance 0.05 Pain Relevance 0.16
The presence of the transgene is sufficient to suppress the protein expression of VCAM-1 relative to WT and apoE?
Negative_regulation (suppress) of Gene_expression (expression) of VCAM-1
6) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2423484 Disease Relevance 0.39 Pain Relevance 0.03
As shown in Figs. 3 and 4, an increase in the expression of VCAM-1 was observed during prolonged allergen challenge, while administration of sTNFR considerably decreased the VCAM-1 expression.


Negative_regulation (decreased) of Gene_expression (expression) of VCAM-1
7) Confidence 0.31 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 0.63 Pain Relevance 0.32
Moreover, licofelone treatment (30 microM) attenuated expression of VCAM-1 and ICAM-1 on inflammatory EC.
Negative_regulation (attenuated) of Gene_expression (expression) of VCAM-1 associated with inflammation and licofelone
8) Confidence 0.29 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15894291 Disease Relevance 0.47 Pain Relevance 1.12
Recent studies have shown that cytokine-induced expression of VCAM-1, ICAM-1, and E-selectin is inhibited by HDL (Cockerill et al 1995; Ashby et al 1998; Nofer et al 2003; Barter et al 2004).
Negative_regulation (inhibited) of Gene_expression (expression) of VCAM-1 associated with disorder of lipid metabolism and cytokine
9) Confidence 0.26 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.00 Pain Relevance 0.15
Analyses at both cellular and molecular levels to a penetrating neocortical injury in mice that lack IL-1R1 demonstrated: diminished responsiveness of macrophages and microglia, deficient recruitment of peripheral macrophages, attenuated production of the vascular cell adhesion molecule-1 (VCAM-1), attenuated cyclooxygenase-2 production and attenuated levels of pro-inflammatory cytokine mRNAs.
Negative_regulation (attenuated) of Gene_expression (production) of VCAM-1 in macrophages associated with inflammation, injury, adhesions and cytokine
10) Confidence 0.26 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 1.12 Pain Relevance 0.31
Because soluble VCAM-1 results from the cleavage of its bound form, increased serum levels of soluble VCAM-1 might reflect a decrease in VCAM-1 expression on endothelium in MS patients treated with IFN-?.
Negative_regulation (decrease) of Gene_expression (expression) of VCAM-1 in endothelium associated with multiple sclerosis
11) Confidence 0.24 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 1.48 Pain Relevance 0.66
In EAE, expression of ICAM-1 and VCAM-1 correlates with disease phase, specifically upregulation during the initial phase and decreased expression during disease remission [32].
Negative_regulation (decreased) of Gene_expression (expression) of VCAM-1 associated with multiple sclerosis and disease
12) Confidence 0.23 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 1.25 Pain Relevance 0.57
Biochemical and histological studies revealed that the Protandim diet suppressed tumor promoter-induced oxidative stress (evidenced by reduction of protein carbonyl levels), cell proliferation (evidenced by reduction of skin hyperplasia and suppression of PKC/JNK/Jun pathway), and inflammation (evidenced by reduction of ICAM-1/VCAM-1 expression, NF-?
Negative_regulation (reduction) of Gene_expression (expression) of VCAM-1 in skin associated with stress, inflammation, cancer and skin cancer
13) Confidence 0.22 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2668769 Disease Relevance 0.73 Pain Relevance 0.05
It also decreases the expression of adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattract protein-1 (MCP-1).
Negative_regulation (decreases) of Gene_expression (expression) of vascular cell adhesion molecule-1 in monocyte associated with adhesions
14) Confidence 0.19 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.35 Pain Relevance 0
ligands inhibit the expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 and decreased production of chemokines, such as IL-8 and monocyte chemotactic protein-1 (MCP-1) via suppressions of AP-1 and NF-?
Negative_regulation (inhibit) of Gene_expression (production) of VCAM-1 in monocyte associated with chemokine and adhesions
15) Confidence 0.18 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 1.06 Pain Relevance 0.17
ligands inhibit the expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 and decreased production of chemokines, such as IL-8 and monocyte chemotactic protein-1 (MCP-1) via suppressions of AP-1 and NF-?
Negative_regulation (inhibit) of Gene_expression (expression) of VCAM-1 in monocyte associated with chemokine and adhesions
16) Confidence 0.18 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 1.06 Pain Relevance 0.17
ligands inhibit the expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 and decreased production of chemokines, such as IL-8 and monocyte chemotactic protein-1 (MCP-1) via suppressions of AP-1 and NF-?
Negative_regulation (decreased) of Gene_expression (production) of VCAM-1 in monocyte associated with chemokine and adhesions
17) Confidence 0.18 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 0.99 Pain Relevance 0.16
It also decreases the expression of adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattract protein-1 (MCP-1).
Negative_regulation (decreases) of Gene_expression (expression) of VCAM-1 in monocyte associated with adhesions
18) Confidence 0.14 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.35 Pain Relevance 0
In older patients, ARBs reduced circulating levels of VCAM-1 but not of E-selectin (Rajagopalan et al 2002).
Negative_regulation (reduced) of Gene_expression (levels) of VCAM
19) Confidence 0.13 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 1.25 Pain Relevance 0.30
decreases severity of atherosclerosis through the increased expression of VCAM-1 and MCP-1 [84, 85].


Negative_regulation (decreases) of Gene_expression (expression) of VCAM-1 associated with atherosclerosis
20) Confidence 0.13 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2841501 Disease Relevance 1.12 Pain Relevance 0.37

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