INT127038

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Context Info
Confidence 0.72
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 3.94
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Alas1) biosynthetic process (Alas1) nucleus (Alas1)
transferase activity, transferring acyl groups (Alas1) cytoplasm (Alas1)
Anatomy Link Frequency
liver 2
Alas1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 4 96.92 Very High Very High Very High
Cannabinoid 6 96.08 Very High Very High Very High
abdominal pain 6 93.44 High High
Pain 14 92.84 High High
peripheral neuropathy 6 85.44 High High
Analgesic 2 83.92 Quite High
anesthesia 8 53.64 Quite High
Bile 18 33.04 Quite Low
Inflammation 9 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Porphyria 140 99.70 Very High Very High Very High
Abdominal Pain 6 93.44 High High
Pain 4 92.84 High High
Psychosis 3 91.92 High High
Erythropoietic Protoporphyria 176 89.48 High High
Hepatic Porphyrias 32 86.36 High High
Peripheral Neuropathy 6 85.44 High High
Blister 8 80.40 Quite High
Nicotine Addiction 5 75.68 Quite High
Disease 204 68.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To this end, hepatic activities of aminolevulinic acid synthase (ALAS), heme oxygenase (HO) and CYP levels were determined in mice treated with CP-55,940 (0.5 mg/kg/day; i.p.; 5 or 24 days).
Gene_expression (levels) of aminolevulinic acid synthase
1) Confidence 0.72 Published 2005 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 15896668 Disease Relevance 0.18 Pain Relevance 0.46
To this end, hepatic activities of aminolevulinic acid synthase (ALAS), heme oxygenase (HO) and CYP levels were determined in mice treated with CP-55,940 (0.5 mg/kg/day; i.p.; 5 or 24 days).
Gene_expression (levels) of ALAS
2) Confidence 0.72 Published 2005 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 15896668 Disease Relevance 0.18 Pain Relevance 0.45
Importantly, the PAR bZip genes control expression of two genes essential for xenobiotic metabolism: aminolevulinic acid synthase (ALAS1) and POR, with a 2.0-fold and 2.9-fold higher expression in GF mice respectively [22].
Gene_expression (expression) of ALAS1
3) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0.05
ALAS is the first enzyme of the haem synthetic pathway, which is synthesised by two different genes: ALAS1 in the liver and other tissues located on chromosome 3, and ALAS2 in the erythroid tissue located on chromosome X.
Gene_expression (synthesised) of ALAS1 in liver
4) Confidence 0.52 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2747912 Disease Relevance 0.79 Pain Relevance 0.08
ALAS is the first enzyme of the haem synthetic pathway, which is synthesised by two different genes: ALAS1 in the liver and other tissues located on chromosome 3, and ALAS2 in the erythroid tissue located on chromosome X.
Gene_expression (synthesised) of ALAS in liver
5) Confidence 0.45 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2747912 Disease Relevance 0.75 Pain Relevance 0.08
greatly increases hepatic ALAS expression by activating transcription
Gene_expression (expression) of ALAS
6) Confidence 0.22 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559910 Disease Relevance 0.48 Pain Relevance 0.13
In addition, ALAS may
Spec (may) Gene_expression (may) of ALAS
7) Confidence 0.19 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559910 Disease Relevance 0.49 Pain Relevance 0.14
the heme biosynthesis pathway, that enzyme and not ALAS is the
Gene_expression (enzyme) of ALAS associated with porphyria
8) Confidence 0.19 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559910 Disease Relevance 1.07 Pain Relevance 0.09

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