INT127039

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Context Info
Confidence 0.21
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 5.29
Pain Relevance 3.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ppig) protein folding (Ppig) nucleus (Ppig)
cytoplasm (Ppig)
Anatomy Link Frequency
liver 3
plasma 1
spleen 1
immune system 1
T cells 1
Ppig (Mus musculus)
Pain Link Frequency Relevance Heat
depression 48 100.00 Very High Very High Very High
Paracetamol 39 99.92 Very High Very High Very High
Leflunomide 10 99.66 Very High Very High Very High
Inflammation 96 99.38 Very High Very High Very High
interstitial cystitis 82 94.48 High High
agonist 4 88.88 High High
Cannabinoid 3 88.04 High High
Pain 2 84.80 Quite High
cytokine 40 84.40 Quite High
chemokine 24 83.44 Quite High
Disease Link Frequency Relevance Heat
Depression 48 100.00 Very High Very High Very High
Malaria 270 99.74 Very High Very High Very High
INFLAMMATION 114 99.38 Very High Very High Very High
Cystitis 140 99.24 Very High Very High Very High
Immunization 12 99.08 Very High Very High Very High
Renal Failure 9 99.06 Very High Very High Very High
Hepatotoxicity 5 94.60 High High
Interstitial Cystitis 82 94.48 High High
Infection 382 90.56 High High
Pain 4 84.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results showed that treatment with CP-55,940 decreased CYP concentrations by 80% and increased HO activity by 158%.
Negative_regulation (decreased) of CYP
1) Confidence 0.21 Published 2005 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 15896668 Disease Relevance 0.16 Pain Relevance 0.44
The results indicate that, although CCl(4) reduces the generation of thioether conjugates of acetaminophen by decreasing the CYP activities, inhibition of the oxidative metabolism of acetaminophen is counterbalanced by the enhancement of conjugate formation via the glucuronide and sulfate pathways, resulting in elimination of the drug at a rate equivalent to that in normal mice.
Negative_regulation (decreasing) of CYP associated with paracetamol
2) Confidence 0.19 Published 2006 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 16445600 Disease Relevance 0 Pain Relevance 1.01
Our results show that CXCL10 blockade does not affect the percentage of CD4+ T cells in the spleen of naïve mice, but inhibition of CXCL10 in CYP-treated mice with cystitis lead to an increase in the percentage of T helper splenocytes.
Negative_regulation (inhibition) of CYP in spleen associated with cystitis
3) Confidence 0.11 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.75 Pain Relevance 0.33
The mechanism by which CYP modulates inflammation might be due to the cytotoxic effect of CYP on proliferating CD25+ T cells (e.g., Treg cells).
Negative_regulation (effect) of CYP in T cells associated with inflammation
4) Confidence 0.10 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.52 Pain Relevance 0.23
The mechanism of protection by leflunomide was not through inhibition of cytochrome P450 (CYP)-catalyzed APAP bioactivation or an apparent suppression of the innate immune system.
Negative_regulation (inhibition) of CYP in immune system associated with paracetamol and leflunomide
5) Confidence 0.08 Published 2007 Journal Hepatology Section Abstract Doc Link 17366662 Disease Relevance 0.47 Pain Relevance 1.28
Based on these findings, and also on in vivo experiments in which iNOS inhibitors partially reversed LPS-induced decline of liver CYP activities, Khatsenko et al [16] advanced a hypothesis that NO overproduction mediates the decrease in CYP activities induced by immunostimulation.
Negative_regulation (decrease) of CYP in liver associated with immunization
6) Confidence 0.07 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.47 Pain Relevance 0.09
It has been noted that nitric oxide (NO) causes a concentration-dependent inhibition of CYP activities in liver microsomes in vitro [16,17].
Negative_regulation (inhibition) of CYP in liver
7) Confidence 0.06 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.54 Pain Relevance 0.10
Based on these findings, and also on in vivo experiments in which iNOS inhibitors partially reversed LPS-induced decline of liver CYP activities, Khatsenko et al [16] advanced a hypothesis that NO overproduction mediates the decrease in CYP activities induced by immunostimulation.
Negative_regulation (decline) of CYP in liver associated with immunization
8) Confidence 0.06 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.46 Pain Relevance 0.08
Given the low plasma concentrations of EETs, it is however difficult to imagine that the somewhat modest increase in response to sEH inhibition or renal failure is sufficient to induce a significant product inhibition of the CYP enzymes, although other observations supporting the complex crosstalk have been published for inflammatory models [45].
Negative_regulation (inhibition) of CYP in plasma associated with inflammation and renal failure
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.46 Pain Relevance 0.08
Nonetheless, the idea that NO mediates a general depression of CYP activities caused by inflammatory and infectious stimuli remains controversial.
Negative_regulation (depression) of CYP associated with inflammation and depression
10) Confidence 0.05 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.54 Pain Relevance 0.10
The mechanisms by which malaria up and down-regulates CYP activities are not understood yet.
Negative_regulation (regulates) of CYP associated with malaria
11) Confidence 0.05 Published 2010 Journal Malar J Section Abstract Doc Link PMC2858213 Disease Relevance 0.56 Pain Relevance 0.04
Moreover, the authors pointed out that the foregoing CYP2a5 inducers also up-regulated HO-1, and that CYP2a5 over-expression is often associated with a decrease of total CYP content, which in turn has been shown to be associated with HO-1 induction as well.
Negative_regulation (decrease) of CYP
12) Confidence 0.05 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.34 Pain Relevance 0.04
Thus, a CYP enzymatic activity in the chimeric mice was specifically induced by a CYP2D6-metabolized drug and specifically suppressed by a CYP2D6 inhibitor [25].
Negative_regulation (suppressed) of CYP
13) Confidence 0.04 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0 Pain Relevance 0.06

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