INT127046

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 65
Total Number 68
Disease Relevance 34.28
Pain Relevance 14.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2RX7) cytoplasm (P2RX7)
Anatomy Link Frequency
macrophages 8
microglial cells 5
nerve 5
spinal cord 3
monocytes 3
P2RX7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 826 100.00 Very High Very High Very High
antagonist 406 100.00 Very High Very High Very High
addiction 25 100.00 Very High Very High Very High
substance P 18 100.00 Very High Very High Very High
Potency 94 99.82 Very High Very High Very High
Multiple sclerosis 637 99.80 Very High Very High Very High
Spinal cord 601 99.58 Very High Very High Very High
agonist 438 99.40 Very High Very High Very High
adenocard 143 99.30 Very High Very High Very High
Lasting pain 76 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 937 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 375 100.00 Very High Very High Very High
Nociception 68 99.98 Very High Very High Very High
Demyelinating Disease 676 99.80 Very High Very High Very High
Targeted Disruption 188 99.72 Very High Very High Very High
Motor Neuron Diseases 572 99.52 Very High Very High Very High
Pancreatic Cancer 4 99.48 Very High Very High Very High
Infection 450 99.46 Very High Very High Very High
Hepatitis B Virus Infection 172 99.28 Very High Very High Very High
Sprains And Strains 47 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: These data show that P2X7 is expressed in human lingual nerve neuromas from patients with and without dysesthesia.
Gene_expression (expressed) of P2X7 in nerve
1) Confidence 0.78 Published 2009 Journal J Orofac Pain Section Body Doc Link 19264037 Disease Relevance 0 Pain Relevance 0
RESULTS: P2X7 was found to be expressed in Schwann cells of lingual nerve neuromas.
Gene_expression (expressed) of P2X7 in nerve
2) Confidence 0.78 Published 2009 Journal J Orofac Pain Section Body Doc Link 19264037 Disease Relevance 0 Pain Relevance 0
Indirect immunofluorescence using antibodies raised against S-100 (a Schwann cell marker) and P2X7 was employed to quantify the percentage area of S-100 positive cells that also expressed P2X7.
Gene_expression (expressed) of P2X7 in Schwann cell
3) Confidence 0.78 Published 2009 Journal J Orofac Pain Section Body Doc Link 19264037 Disease Relevance 0 Pain Relevance 0
No significant difference was found between the level of P2X7 expression in patients with or without symptoms of dysesthesia, and no relationship was observed between P2X7 expression and VAS scores for pain, tingling, or discomfort.
Gene_expression (expression) of P2X7
4) Confidence 0.78 Published 2009 Journal J Orofac Pain Section Body Doc Link 19264037 Disease Relevance 0 Pain Relevance 0
No significant difference was found between the level of P2X7 expression in patients with or without symptoms of dysesthesia, and no relationship was observed between P2X7 expression and VAS scores for pain, tingling, or discomfort.
Gene_expression (expression) of P2X7
5) Confidence 0.78 Published 2009 Journal J Orofac Pain Section Body Doc Link 19264037 Disease Relevance 0 Pain Relevance 0
No correlation was found between P2X7 expression and the time between initial injury and nerve repair.
Gene_expression (expression) of P2X7 in nerve
6) Confidence 0.78 Published 2009 Journal J Orofac Pain Section Body Doc Link 19264037 Disease Relevance 0 Pain Relevance 0
AIMS: Recent evidence suggests that the purinoceptor P2X7 may be involved in the development of dysesthesia following nerve injury, therefore, the aim of the present study was to investigate whether a correlation exists between the level of P2X7 receptor expression in damaged human lingual nerves and the severity of the patients' symptoms.
Gene_expression (expression) of P2X7 receptor in nerve associated with dysesthesia and nervous system injury
7) Confidence 0.78 Published 2009 Journal J Orofac Pain Section Abstract Doc Link 19264037 Disease Relevance 0.27 Pain Relevance 0.10
It therefore appears that the level of P2X7 expression at the injury site may not be linked to the maintenance of neuropathic pain after lingual nerve injury.


Gene_expression (expression) of P2X7 in nerve
8) Confidence 0.78 Published 2009 Journal J Orofac Pain Section Body Doc Link 19264037 Disease Relevance 0 Pain Relevance 0
Although P2X7 receptors are frequently coexpressed with another subtype of P2X receptor, P2X4, they are believed not to form heteromeric assemblies but to function only as homomers.
Gene_expression (coexpressed) of P2X7
9) Confidence 0.76 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17785580 Disease Relevance 0.26 Pain Relevance 0.21
Coexpression of a dominant-negative P2X4 mutant (C353W) with P2X7, inhibited P2X7 receptor mediated currents by greater than 2-fold, whereas a nonfunctional but non-dominant-negative mutant (S341W) did not.
Gene_expression (Coexpression) of P2X7
10) Confidence 0.76 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17785580 Disease Relevance 0.21 Pain Relevance 0.22
Coexpression of P2X4S341W with P2X7 produced a current that was potentiated by ivermectin and inhibited by 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5-triphosphate (TNP-ATP), whereas expression of P2X7 alone produced a current that was insensitive to both of these compounds at the concentrations used.
Gene_expression (expression) of P2X7 associated with adenocard
11) Confidence 0.76 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17785580 Disease Relevance 0.12 Pain Relevance 0.17
Coexpression of P2X4S341W with P2X7 produced a current that was potentiated by ivermectin and inhibited by 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5-triphosphate (TNP-ATP), whereas expression of P2X7 alone produced a current that was insensitive to both of these compounds at the concentrations used.
Gene_expression (Coexpression) of P2X7 associated with adenocard
12) Confidence 0.76 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17785580 Disease Relevance 0.18 Pain Relevance 0.20
Structure-activity relationship (SAR) studies evaluated functional activity by monitoring calcium flux inhibition in cell lines expressing recombinant human and rat P2X7 receptors.
Gene_expression (expressing) of P2X7
13) Confidence 0.75 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 18438986 Disease Relevance 0.08 Pain Relevance 0.33
Exogenous expression of human P2X7 cDNA sequences has been previously achieved in the 293T cell line [33].
Gene_expression (expression) of P2X7
14) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004961 Disease Relevance 0.70 Pain Relevance 0
These include P2X7 expression and function vary between tissues and with species [33], human P2X7 exists in at least 7 different spliced forms [36], and there are many genetic polymorphisms [37].
Gene_expression (expression) of P2X7
15) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004961 Disease Relevance 0.76 Pain Relevance 0
CONCLUSION: Substance P receptor expression in human pulp tissue is significantly increased during inflammatory phenomena such as acute irreversible pulpitis.


Gene_expression (expression) of P receptor
16) Confidence 0.70 Published 2007 Journal Int Endod J Section Body Doc Link 17229115 Disease Relevance 0.11 Pain Relevance 0
Substance P receptor expression in healthy and inflamed human pulp tissue.
Gene_expression (expression) of P receptor associated with substance p
17) Confidence 0.70 Published 2007 Journal Int Endod J Section Title Doc Link 17229115 Disease Relevance 0 Pain Relevance 0.23
RESULTS: Substance P receptor expression was found in all human pulp tissue samples.
Gene_expression (expression) of P receptor
18) Confidence 0.70 Published 2007 Journal Int Endod J Section Body Doc Link 17229115 Disease Relevance 0.15 Pain Relevance 0
Heightened expression patterns and localization patterns of CD39, P2X7, and P2Y2 infer associations with chronic inflammation and neoplasia of the pancreas.
Gene_expression (expression) of P2X7 in pancreas associated with inflammation and cancer
19) Confidence 0.68 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16920697 Disease Relevance 1.47 Pain Relevance 0.38
induced by TLR agonists (5), we tested the caspase-1 dependence of the newly identified P2X7 receptor-independent IL-1?
Gene_expression (dependence) of P2X7 associated with addiction and agonist
20) Confidence 0.61 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.10

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