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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.37
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a3)
Anatomy Link Frequency
plasma 2
striatum 2
Slc1a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 6 100.00 Very High Very High Very High
Dopamine 2 100.00 Very High Very High Very High
Dynorphin 4 95.84 Very High Very High Very High
Enkephalin 4 82.72 Quite High
antagonist 1 68.80 Quite High
dopamine receptor 1 60.48 Quite High
GABAergic 1 59.56 Quite High
Migraine 1 57.84 Quite High
Thalamus 1 51.04 Quite High
Disease Link Frequency Relevance Heat
Repression 1 85.84 High High
Headache 1 57.84 Quite High
Manic Depressive Disorder 1 57.32 Quite High
Neurological Disease 1 56.32 Quite High
Disease 1 55.96 Quite High
Epilepsy 1 53.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
L-DOPA treatment increased dopamine D3 receptor and glutamate transporter 1 (GLT1) mRNA expression in the lesioned striatum and that, specifically in an area overlapping one of Nur77 decrease and of NT/DYN induction.
Positive_regulation (increased) of Transcription (expression) of glutamate transporter 1 in striatum associated with glutamate, dopamine and dynorphin
1) Confidence 0.14 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15896973 Disease Relevance 0.06 Pain Relevance 0.62
Long-term valproate treatment up-regulates chglast promoter activity, GLAST mRNA levels, GLAST molecules at the plasma membrane and its uptake activity.
Positive_regulation (up-regulates) of Transcription (levels) of GLAST in plasma
2) Confidence 0.11 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18336953 Disease Relevance 0.31 Pain Relevance 0.26

General Comments

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