INT127052

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.06
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd3) signal transducer activity (Drd3)
Anatomy Link Frequency
striatum 1
Drd3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 208 100.00 Very High Very High Very High
Glutamate 9 100.00 Very High Very High Very High
Dynorphin 4 95.84 Very High Very High Very High
GABAergic 36 86.20 High High
Enkephalin 4 82.32 Quite High
dopamine receptor 59 74.40 Quite High
antagonist 23 68.40 Quite High
Thalamus 15 51.04 Quite High
Substantia nigra 12 16.64 Low Low
gABA 48 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 45 55.56 Quite High
Parkinson's Disease 42 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 6 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 4 5.00 Very Low Very Low Very Low
Movement Disorders 4 5.00 Very Low Very Low Very Low
Tourette's Syndrome 2 5.00 Very Low Very Low Very Low
Fatigue 2 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
L-DOPA treatment increased dopamine D3 receptor and glutamate transporter 1 (GLT1) mRNA expression in the lesioned striatum and that, specifically in an area overlapping one of Nur77 decrease and of NT/DYN induction.
Transcription (expression) of dopamine D3 receptor in striatum associated with glutamate, dopamine and dynorphin
1) Confidence 0.37 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15896973 Disease Relevance 0.06 Pain Relevance 0.62
For example, D2- and (less) D3-receptor mRNA has been found in the human GPe (Murray et al., 1994).
Transcription (found) of D3-receptor
2) Confidence 0.06 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.18
However, another study did not confirm D3-receptor mRNA expression in monkeys (Quik et al., 2000).
Transcription (expression) of D3-receptor
3) Confidence 0.06 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.20

General Comments

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