INT127053

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.80
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a3)
Anatomy Link Frequency
plasma 1
brain 1
striatum 1
Slc1a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 37 100.00 Very High Very High Very High
Dopamine 9 99.66 Very High Very High Very High
nMDA receptor 9 97.32 Very High Very High Very High
Dynorphin 4 95.84 Very High Very High Very High
Glutamate receptor 4 94.56 High High
Nucleus accumbens 13 87.92 High High
Hippocampus 7 86.92 High High
GABAergic 2 86.24 High High
Migraine 2 84.52 Quite High
Enkephalin 4 81.32 Quite High
Disease Link Frequency Relevance Heat
Repression 2 85.84 High High
Headache 2 84.52 Quite High
Manic Depressive Disorder 2 84.00 Quite High
Neurological Disease 2 83.00 Quite High
Epilepsy 2 80.56 Quite High
Schizophrenia 5 55.12 Quite High
Disease 2 54.56 Quite High
Death 1 48.64 Quite Low
Amnesia 2 14.72 Low Low
Cognitive Disorder 5 13.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mRNA levels of glutamate transporters (EAAT1, EAAT2-1, EAAT2-2), AMPA receptor subunits (GluR1, GluR2, GluR3), NMDA receptor subunits (NR1, NR2A and NR2B), as well as metabotropic glutamate receptors (mGluR1, mGluR2, mGluR3, mGluR5) were confirmed in six regions of the male rat brain (the prefrontal cortex (PFC), cortex, caudate putamen (CPU), nucleus accumbens (Acb), hippocampus and hypothalamus.
Transcription (levels) of EAAT1 in brain associated with nucleus accumbens, glutamate, glutamate receptor, nmda receptor and hippocampus
1) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0.11 Pain Relevance 0.66
L-DOPA treatment increased dopamine D3 receptor and glutamate transporter 1 (GLT1) mRNA expression in the lesioned striatum and that, specifically in an area overlapping one of Nur77 decrease and of NT/DYN induction.
Transcription (expression) of glutamate transporter 1 in striatum associated with glutamate, dopamine and dynorphin
2) Confidence 0.20 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15896973 Disease Relevance 0.05 Pain Relevance 0.61
The glutamate/aspartate transporter GLAST/EAAT1 plays the major role in glutamate removal and is regulated at different levels: transcription, post-translational modifications and cytoplasmic trafficking.
Transcription (transcription) of GLAST associated with glutamate
3) Confidence 0.15 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18336953 Disease Relevance 0.33 Pain Relevance 0.37
Long-term valproate treatment up-regulates chglast promoter activity, GLAST mRNA levels, GLAST molecules at the plasma membrane and its uptake activity.
Transcription (levels) of GLAST in plasma
4) Confidence 0.13 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18336953 Disease Relevance 0.30 Pain Relevance 0.26

General Comments

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