INT127060

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.27
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF3) nucleolus (ATF3) nucleus (ATF3)
ATF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 14 93.08 High High
COX-2 inhibitor 6 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 22 100.00 Very High Very High Very High
Cancer 239 99.84 Very High Very High Very High
Metastasis 44 99.84 Very High Very High Very High
Colorectal Cancer 4 99.60 Very High Very High Very High
Colon Cancer 153 98.00 Very High Very High Very High
Carcinoma 15 96.28 Very High Very High Very High
INFLAMMATION 8 92.56 High High
Stress 15 70.64 Quite High
Pressure And Volume Under Development 6 53.84 Quite High
Shock 24 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of SAPK (SP600125) most robustly up-regulated ATF3 mRNA expression (Figure 2A).
Negative_regulation (Inhibition) of Gene_expression (expression) of ATF3 mRNA
1) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.65 Pain Relevance 0
The effects of diminished ATF3 expression on tumor growth in vivo were first investigated in a subcutaneous tumor model using HCT116 cells.
Negative_regulation (diminished) of Gene_expression (expression) of ATF3 associated with cancer
2) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.10 Pain Relevance 0
We next tested the effects of inhibited ATF3 expression on tumor metastasis in vivo in a model of hepatic tumor growth and in a model of peritoneal carcinomatosis.
Negative_regulation (inhibited) of Gene_expression (expression) of ATF3 associated with cancer, carcinoma and metastasis
3) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.49 Pain Relevance 0
Activating transcription factor 3 (ATF3) was selected for further study because it is a transcription factor involved in cell proliferation, apoptosis, and invasion, and its expression is repressed in human colorectal tumors as compared with normal adjacent tissue.
Negative_regulation (repressed) of Gene_expression (expression) of ATF3 associated with colorectal cancer and apoptosis
4) Confidence 0.43 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15897233 Disease Relevance 0.44 Pain Relevance 0.27
Overexpression of ATF3 in the sense orientation decreased focus formation in vitro and reduced the size of mouse tumor xenografts by 54% in vivo.
Negative_regulation (reduced) of Gene_expression (Overexpression) of ATF3 associated with cancer
5) Confidence 0.43 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15897233 Disease Relevance 0.59 Pain Relevance 0.23

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox