INT127062

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 22
Disease Relevance 15.90
Pain Relevance 5.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (LTB4R) signal transducer activity (LTB4R)
Anatomy Link Frequency
osteoblasts 8
blood 2
macrophages 2
chondrocytes 2
nasal 2
LTB4R (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 16 99.92 Very High Very High Very High
Osteoarthritis 764 99.84 Very High Very High Very High
COX-2 inhibitor 42 99.72 Very High Very High Very High
corticosteroid 174 99.40 Very High Very High Very High
cINOD 158 99.36 Very High Very High Very High
diclofenac 13 98.80 Very High Very High Very High
Pain 35 95.36 Very High Very High Very High
Inflammation 390 95.08 Very High Very High Very High
aspirin 24 94.72 High High
Inflammatory marker 6 94.00 High High
Disease Link Frequency Relevance Heat
Osteoarthritis 782 99.84 Very High Very High Very High
Occupational Lung Diseases 185 99.76 Very High Very High Very High
Asthma 542 99.48 Very High Very High Very High
Hypersensitivity 11 99.08 Very High Very High Very High
INFLAMMATION 485 98.48 Very High Very High Very High
Nasal Polyps 48 97.92 Very High Very High Very High
Rhinitis 47 97.68 Very High Very High Very High
Cough 91 97.04 Very High Very High Very High
Pain 39 95.36 Very High Very High Very High
Disease 72 91.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several synthetic LTB4 receptor
Positive_regulation (Several) of Gene_expression (Several) of LTB4
1) Confidence 0.34 Published 2008 Journal PPAR Research Section Body Doc Link PMC2631651 Disease Relevance 0.28 Pain Relevance 0.22
However are in contrast with other reports showing increased levels of LTB4 and BLT receptors in allergic versus non-allergic nasal polyp patients [10].
Positive_regulation (increased) of Gene_expression (levels) of LTB4 in nasal associated with hypersensitivity and nasal polyps
2) Confidence 0.29 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.35 Pain Relevance 0.12
While concentrations of LTC4/D4/E4, were significantly higher in CRS-NP compared to CRS and controls, no differences were observed in LTB4 levels between the groups.
Positive_regulation (observed) of Gene_expression (levels) of LTB4
3) Confidence 0.27 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.42 Pain Relevance 0.12
Regarding calcium ionophore-induced LTB4 biosynthesis by AMs, one study reported increased LTB4 generation by cells in asthma compared to non-asthmatics [31], while another study did not report any significant differences[29].
Positive_regulation (induced) of Gene_expression (biosynthesis) of LTB4 associated with asthma and occupational lung diseases
4) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.11 Pain Relevance 0.03
Thus, there is an increase in mediator expression as measured by increased levels of histamine in bronchoalveolar lavage fluid, and levels of cys-leukotrienes, leukotriene B4, myeloperoxidase and TNF?
Positive_regulation (increased) of Gene_expression (levels) of leukotriene B4
5) Confidence 0.03 Published 2009 Journal Respir Res Section Body Doc Link PMC2688489 Disease Relevance 1.50 Pain Relevance 0.12
The LTB4 production induced by LPS is shown as increments in LTB4 above baseline (Figure 2B).
Positive_regulation (increments) of Gene_expression (production) of LTB4
6) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 0.82 Pain Relevance 0.14
A total of 23 reaction constants was taken from experimental values, while the others were obtained by fitting the calculated production of LTB4 and its ?
Positive_regulation (calculated) of Gene_expression (production) of LTB4
7) Confidence 0.02 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1829479 Disease Relevance 0.51 Pain Relevance 0.26
A total of 23 reaction constants was taken from experimental values, while the others were obtained by fitting the calculated production of LTB4 and its ?
Positive_regulation (obtained) of Gene_expression (production) of LTB4
8) Confidence 0.02 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1829479 Disease Relevance 0.51 Pain Relevance 0.26
Using a similar method as our study to distinguish severe from non-severe asthma, a deficiency in both baseline and divalent cation ionophore-stimulated production of LXA4 in whole blood of patients with severe asthma compared to moderate asthma was established, while the production of cysteinyl-leukotrienes and LTB4 were increased[9].
Positive_regulation (increased) of Gene_expression (production) of LTB4 in blood associated with asthma
9) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.37 Pain Relevance 0.08
Decreased LXA4 and increased LTB4 generation plus impaired corticosteroid sensitivity of LPS-induced LTB4 but not of LXA4 support a role for AMs in establishing a pro-inflammatory balance in severe asthma.



Positive_regulation (increased) of Gene_expression (generation) of LTB4 associated with asthma, corticosteroid and inflammation
10) Confidence 0.02 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2894769 Disease Relevance 1.07 Pain Relevance 0.27
Regarding calcium ionophore-induced LTB4 biosynthesis by AMs, one study reported increased LTB4 generation by cells in asthma compared to non-asthmatics [31], while another study did not report any significant differences[29].
Positive_regulation (increased) of Gene_expression (generation) of LTB4 associated with asthma and occupational lung diseases
11) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.11 Pain Relevance 0.03
The first significant elevation in PGE 2 and LTB 4 levels and MPO activity were observed in stage III.
Positive_regulation (elevation) of Gene_expression (levels) of LTB 4
12) Confidence 0.02 Published 2005 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 15897851 Disease Relevance 0.08 Pain Relevance 0
The production of both PGE2 and LTB4 requires AA; therefore, one of the pathways is used favorably, depending on the condition.
Positive_regulation (requires) of Gene_expression (production) of LTB4
13) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.84 Pain Relevance 0.56
Other studies, however, have demonstrated that the increase in LTB4 production was mainly related to upregulation of the FLAP gene [39] or to a combination of an increment in the activity and/or expression of 5-LOX [40,41].
Positive_regulation (increase) of Gene_expression (production) of LTB4
14) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.06 Pain Relevance 0.03
These results are consistent with a previous report of Martel-Pelletier and colleagues showing that 5-LOX expression is activated after that of FLAP, leading to the late increase of LTB4 production [28].
Positive_regulation (increase) of Gene_expression (production) of LTB4
15) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.13 Pain Relevance 0.07
The present study demonstrated that the induction of LTB4 production in response to NSAIDs or NS-398 in OA osteoblasts involved no major modification of 5-LO expression, in contrast to the situation observed in OA chondrocytes [56].
Positive_regulation (induction) of Gene_expression (production) of LTB4 in chondrocytes associated with cinod and osteoarthritis
16) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 1.01 Pain Relevance 0.83
Curiously, the occurrence of corneal infiltrates concomitantly with use of oral diclofenac has also been reported and is thought to be related to the increased production of lipoxygenase-derived LTB4, a polymorphonuclear chemotactic (Tabbara 2000).
Positive_regulation (increased) of Gene_expression (production) of LTB4 associated with diclofenac
17) Confidence 0.01 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693998 Disease Relevance 0.19 Pain Relevance 0.47
or a combination of the two with an increase in LTB4 production, regardless of their endogenous PGE2 production; data were therefore pooled for both groups of OA osteoblasts.
Positive_regulation (increase) of Gene_expression (production) of LTB4 in osteoblasts associated with osteoarthritis
18) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.62 Pain Relevance 0.34
In macrophages, the shunt from the COX to the 5-LO pathway is linked with a variable production of IL-10; as PGE2 levels rise, IL-10 levels increase and inhibit the synthesis of LTB4 [24].
Positive_regulation (increase) of Gene_expression (synthesis) of LTB4 in macrophages
19) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.54 Pain Relevance 0.27
Such an increase in FLAP expression in response to NS-398 could explain our previous observation of an increase in LTB4 production by OA osteoblasts under similar conditions [12].
Positive_regulation (increase) of Gene_expression (production) of LTB4 in osteoblasts associated with osteoarthritis
20) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.67 Pain Relevance 0.37

General Comments

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