INT127064

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 1.71
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT76) cytoskeleton organization (KRT76)
Anatomy Link Frequency
myometrium 2
uterine muscle 1
gingiva 1
pore 1
central nervous system 1
KRT76 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 89 100.00 Very High Very High Very High
Central nervous system 1 99.68 Very High Very High Very High
local anesthetic 7 91.32 High High
Neuronal excitability 1 74.40 Quite High
halothane 1 61.44 Quite High
antagonist 11 44.24 Quite Low
antidepressant 1 34.16 Quite Low
fluoxetine 1 32.96 Quite Low
Cannabinoid 1 27.12 Quite Low
depression 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 147 99.62 Very High Very High Very High
Breast Cancer 34 95.76 Very High Very High Very High
Pre-term Labor 15 94.32 High High
Adenocarcinoma 47 89.72 High High
Apoptosis 51 89.40 High High
Ductal Carcinoma 1 87.00 High High
Malignant Neoplastic Disease 10 84.00 Quite High
Transitional Cell Carcinoma 9 82.48 Quite High
Toxicity 2 75.00 Quite High
Skin Cancer 29 55.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
K76 (previously designated K2p) is specifically expressed in suprabasal cell layers of oral masticatory epithelium, i.e. the slightly orthokeratinized stratified squamous epithelium lining the gingiva and the hard palate (Collin et al. 1992b).
Gene_expression (expressed) of K2p in gingiva
1) Confidence 0.75 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.77 Pain Relevance 0
K2P channels are widely expressed in the central nervous system and are involved in the control of the resting membrane potential and the firing pattern of excitable cells.
Gene_expression (expressed) of K2P in central nervous system associated with central nervous system
2) Confidence 0.68 Published 2005 Journal Reg Anesth Pain Med Section Abstract Doc Link 15898030 Disease Relevance 0.07 Pain Relevance 0.34
We used average cluster linkage, uncentered [31] based on Euclidean distance and removed all genes that were turned on in tumors but that were not expressed in normal tissue (NCK5AI, CDK5 activator, CDC25A, ERK4, K2P, COL11A1, OBCAM, AMPHIREGULIN, BCGF1 and BMP8).
Neg (not) Gene_expression (expressed) of K2P associated with cancer
3) Confidence 0.50 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.53 Pain Relevance 0
Examination of the literature reveals conflicting evidence for the expression of these K2P channels in uterine muscle [18], [20], [27], [28].
Gene_expression (expression) of K2P in uterine muscle associated with potassium channel
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0.06 Pain Relevance 0.21
The stretch-activated channel TREK-1 was previously reported to only be minimally expressed in human myometrium [20], [28], [37], while the K2P channels TREK-2 and TRAAK were thought not to be expressed in this tissue at all [18], [20], [38].
Neg (not) Gene_expression (expressed) of K2P in myometrium associated with potassium channel
5) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0.09 Pain Relevance 0.12
We determined the gene and protein expression of K2P channels in non-pregnant, pregnant term and preterm laboring myometrium.
Gene_expression (expression) of K2P in myometrium associated with potassium channel
6) Confidence 0.35 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2928262 Disease Relevance 0 Pain Relevance 0.19
Two-pore domain potassium (K2P) channels are expressed in cells throughout the body and give rise to leak potassium currents which control the excitability of these cells.
Gene_expression (expressed) of K2P in pore
7) Confidence 0.27 Published 2007 Journal Curr Opin Investig Drugs Section Abstract Doc Link 17659475 Disease Relevance 0 Pain Relevance 0.07
This goal will be facilitated by characterization of native K2P channel isoforms, their pharmacological properties and tissue-specific expression patterns.
Gene_expression (expression) of K2P
8) Confidence 0.18 Published 2007 Journal Cell Biochem. Biophys. Section Abstract Doc Link 17652773 Disease Relevance 0.08 Pain Relevance 0.09
K2P channels are expressed in cells throughout the body and have been implicated in diverse cellular functions including maintenance of the resting potential and regulation of excitability, sensory transduction, ion transport, and cell volume regulation, as well as metabolic regulation and apoptosis.
Gene_expression (expressed) of K2P in body associated with apoptosis
9) Confidence 0.18 Published 2007 Journal Cell Biochem. Biophys. Section Abstract Doc Link 17652773 Disease Relevance 0.09 Pain Relevance 0.07

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