INT12707

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1985
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 1.45
Pain Relevance 3.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FPR1) signal transduction (FPR1) plasma membrane (FPR1)
signal transducer activity (FPR1)
Anatomy Link Frequency
neutrophil 6
FPR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 25 99.98 Very High Very High Very High
Paracetamol 3 99.96 Very High Very High Very High
IPN 19 99.56 Very High Very High Very High
agonist 17 99.36 Very High Very High Very High
diclofenac 12 99.08 Very High Very High Very High
Potency 1 98.52 Very High Very High Very High
Opioid 67 98.04 Very High Very High Very High
Enkephalin 40 97.52 Very High Very High Very High
Analgesic 6 93.64 High High
Kinase C 1 91.12 High High
Disease Link Frequency Relevance Heat
Inflammatory Pain 19 99.56 Very High Very High Very High
INFLAMMATION 59 87.80 High High
Disease 9 79.52 Quite High
Crystal Associated Disease 2 78.16 Quite High
Gastritis 2 75.00 Quite High
Sprains And Strains 2 58.08 Quite High
Nociception 24 50.00 Quite Low
Ulcers 1 49.44 Quite Low
Pain 29 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In general, drugs that inhibited O2-. production inhibited fMLP-receptor interactions in a consistent dose dependent fashion, showing noncompetitive kinetics.
Negative_regulation (inhibited) of fMLP-receptor Binding (interactions) of
1) Confidence 0.59 Published 1985 Journal J. Rheumatol. Section Abstract Doc Link 2997448 Disease Relevance 0.39 Pain Relevance 0.26
NSAIDs, but not acetaminophen, inhibited binding of radiolabeled FMLP to purified neutrophil membranes.
Negative_regulation (inhibited) of FMLP Binding (binding) of in neutrophil associated with paracetamol and cinod
2) Confidence 0.51 Published 1990 Journal Inflammation Section Abstract Doc Link 2138998 Disease Relevance 0.16 Pain Relevance 0.71
All three NSAID inhibited FMLP binding in a dose dependent manner with the potency order being meclofenamate greater than ibuprofen greater than tolmetin.
Negative_regulation (inhibited) of FMLP Binding (binding) of associated with cinod and potency
3) Confidence 0.43 Published 1989 Journal Gen. Pharmacol. Section Abstract Doc Link 2545509 Disease Relevance 0.07 Pain Relevance 0.22
Three levels of effects were studied: (1) overall inhibition of O2-. production, (2) the inhibition of interaction between fMLP and specific receptors at the cell surface, and (3) intermediate proenzyme and enzyme effects.
Negative_regulation (inhibition) of fMLP Binding (interaction) of
4) Confidence 0.43 Published 1985 Journal J. Rheumatol. Section Abstract Doc Link 2997448 Disease Relevance 0.35 Pain Relevance 0.20
At drug concentrations causing a significant suppression of O2- generation, diclofenac showed a slight and tolfenamic acid a marked inhibition of [3H]FMLP binding to its cellular receptor; indomethacin has earlier been shown to inhibit FMLP-binding slightly.
Negative_regulation (inhibition) of FMLP Binding (binding) of associated with diclofenac
5) Confidence 0.34 Published 1986 Journal Scand. J. Rheumatol. Section Abstract Doc Link 3008321 Disease Relevance 0.07 Pain Relevance 0.27
Specific binding of [3H]fMLP to neutrophils was inhibited by the three NSAIDs tested in a dose-dependent fashion and tenoxicam was the most potent.
Negative_regulation (inhibited) of fMLP Binding (binding) of in neutrophils associated with cinod
6) Confidence 0.32 Published 1991 Journal Pharmacol. Res. Section Abstract Doc Link 1652137 Disease Relevance 0 Pain Relevance 0.42
The mechanism of inhibition of [3H]fMLP binding by tenoxicam was non-competitive.
Negative_regulation (inhibition) of fMLP Binding (binding) of
7) Confidence 0.32 Published 1991 Journal Pharmacol. Res. Section Abstract Doc Link 1652137 Disease Relevance 0 Pain Relevance 0.40
Blockade of FPR in vivo increased inflammatory pain by inhibiting tonic opioid peptide release
Negative_regulation (Blockade) of FPR Binding (in vivo) of associated with ipn and opioid
8) Confidence 0.25 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.10 Pain Relevance 1.02
In conclusion, rebamipide has the ability to diminish the oxidative burst of neutrophils activated by nonopsonized or opsonized H. pylori organisms with neutrophil activating capacity, most likely through the blocking of fMLP-related receptors, inhibition of the production of reactive oxygen species, and the scavenging of such metabolites.
Negative_regulation (blocking) of fMLP Neg (inhibition) Spec (likely) Binding (diminish) of in neutrophil
9) Confidence 0.19 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753245 Disease Relevance 0.18 Pain Relevance 0.09
Inhibition of surface protein upregulation by FMLP was not due to inhibition of FMLP binding to PMNs.
Negative_regulation (inhibition) of FMLP Binding (binding) of
10) Confidence 0.11 Published 1990 Journal Inflammation Section Abstract Doc Link 2138999 Disease Relevance 0.13 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox