INT127103

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.46
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx1) protein complex (P2rx1)
P2rx1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 78 100.00 Very High Very High Very High
antagonist 26 100.00 Very High Very High Very High
adenocard 11 100.00 Very High Very High Very High
central sensitization 8 99.68 Very High Very High Very High
intrathecal 1 92.04 High High
medulla 1 83.60 Quite High
ischemia 17 79.28 Quite High
Dorsal horn 4 75.00 Quite High
Potency 29 70.08 Quite High
Inflammation 8 47.64 Quite Low
Disease Link Frequency Relevance Heat
Nociception 5 91.52 High High
Neurodegenerative Disease 38 80.80 Quite High
Cv Unclassified Under Development 13 79.28 Quite High
Toxicity 1 68.00 Quite High
Injury 1 48.04 Quite Low
INFLAMMATION 7 47.64 Quite Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low
Coagulation Disorder 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M) was ineffective as an agonist at P2X1 receptors, however, responses were evoked at 100 ?
Negative_regulation (agonist) of Gene_expression (receptors) of P2X associated with agonist
1) Confidence 0.41 Published 2009 Journal Neuropharmacology Section Body Doc Link PMC2613953 Disease Relevance 0 Pain Relevance 0.05
A stock solution of P2X1 antibody (0.3 mg/ml) (Alomone, Israel) was prepared and 3 ?
Negative_regulation (prepared) of Gene_expression (antibody) of P2X
2) Confidence 0.41 Published 2009 Journal Neuropharmacology Section Body Doc Link PMC2613953 Disease Relevance 0 Pain Relevance 0
Superfusion of the selective P2X1, P2X3 and P2X(2/3) receptor antagonist 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (6-638 microM) partially blocked the Vc central sensitization.
Negative_regulation (blocked) of Gene_expression (Superfusion) of P2X1 associated with adenocard, central sensitization and antagonist
3) Confidence 0.38 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 15901761 Disease Relevance 0.24 Pain Relevance 0.67
However, at P2X1 receptors, Phe291Cys was inhibited by both positive and negatively charged MTS reagents demonstrating accessibility and suggesting that it contributes to the ATP binding pocket.
Negative_regulation (inhibited) of Gene_expression (receptors) of P2X1
4) Confidence 0.20 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2972645 Disease Relevance 0 Pain Relevance 0.15
PPADS added during OGD inhibited the expression of P2X1 and P2X6, but not P2X7.
Negative_regulation (inhibited) of Gene_expression (expression) of P2X1
5) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669296 Disease Relevance 0.23 Pain Relevance 0.04

General Comments

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