INT127104

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.71
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (P2rx6)
Anatomy Link Frequency
neurons 2
microglia 1
P2rx6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 22 100.00 Very High Very High Very High
central sensitization 8 99.60 Very High Very High Very High
Hyperalgesia 4 99.48 Very High Very High Very High
Pain 7 98.96 Very High Very High Very High
adenocard 14 98.76 Very High Very High Very High
Morphine 2 97.20 Very High Very High Very High
tolerance 1 96.84 Very High Very High Very High
Opioid 1 94.84 High High
Pain management 1 93.48 High High
Central nervous system 13 90.20 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 5 99.48 Very High Very High Very High
Nociception 8 99.44 Very High Very High Very High
Pain 9 98.96 Very High Very High Very High
Burns 17 98.72 Very High Very High Very High
Injury 14 98.52 Very High Very High Very High
Ganglion Cysts 3 84.96 Quite High
INFLAMMATION 6 39.60 Quite Low
Neurodegenerative Disease 13 5.00 Very Low Very Low Very Low
Disease 11 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of tetramethylpyrazine on DRG neuron P2X3 receptor involved in transmitting pain after burn.
Regulation (Effect) of P2X3 receptor in neuron associated with pain and burns
1) Confidence 0.23 Published 2010 Journal Burns Section Title Doc Link 19726132 Disease Relevance 0.58 Pain Relevance 0.56
The two P2X receptor antagonists did not significantly affect the baseline nociceptive properties of the Vc neurons.
Neg (not) Regulation (affect) of P2X receptor in neurons associated with nociception and antagonist
2) Confidence 0.16 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 15901761 Disease Relevance 0.23 Pain Relevance 0.64
BACKGROUND: The present study examined the effect of P2X receptor antagonist 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP) on morphine tolerance in rats.
Spec (examined) Regulation (effect) of P2X receptor associated with adenocard, antagonist, tolerance and morphine
3) Confidence 0.09 Published 2010 Journal Anesthesiology Section Abstract Doc Link 20938337 Disease Relevance 0 Pain Relevance 0.40
Effect of puerarin on P2X3 receptor involved in hyperalgesia after burn injury in the rat.
Regulation (Effect) of P2X3 receptor associated with hyperalgesia, burns and injury
4) Confidence 0.03 Published 2009 Journal Brain Res. Bull. Section Title Doc Link 19744545 Disease Relevance 1.90 Pain Relevance 0.47
P2X5 receptor immunoreactivity was also upregulated in microglia and granular cells.
Regulation (immunoreactivity) of P2X5 receptor in microglia
5) Confidence 0.02 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0 Pain Relevance 0.15

General Comments

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