INT127112

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Context Info
Confidence 0.80
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 22
Disease Relevance 11.01
Pain Relevance 5.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smad2) DNA binding (Smad2) protein complex (Smad2)
transcription factor binding (Smad2) cytoplasm (Smad2)
Anatomy Link Frequency
frontal cortex 3
kidney 2
hippocampus 2
brain 1
myotubes 1
Smad2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 57 99.84 Very High Very High Very High
Desipramine 7 99.72 Very High Very High Very High
Hippocampus 45 99.52 Very High Very High Very High
fluoxetine 54 99.26 Very High Very High Very High
metalloproteinase 90 96.00 Very High Very High Very High
Inflammation 36 94.08 High High
fibrosis 69 91.92 High High
depression 10 85.28 High High
cytokine 21 84.24 Quite High
Eae 21 84.00 Quite High
Disease Link Frequency Relevance Heat
Stress 52 99.90 Very High Very High Very High
Urological Neuroanatomy 24 99.68 Very High Very High Very High
Cirrhosis 324 99.44 Very High Very High Very High
Apoptosis 95 99.36 Very High Very High Very High
Convulsion 22 98.40 Very High Very High Very High
Ureteral Obstruction 100 96.76 Very High Very High Very High
Cancer 18 96.16 Very High Very High Very High
INFLAMMATION 32 94.08 High High
Internal Fibrosis 4 92.20 High High
Injury 33 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The current study examines the influence of chronic electroconvulsive seizures (ECSs), as well as chemical antidepressants, on the expression of activin betaA and the phosphorylation of Smad2 in the rat hippocampus and frontal cortex.
Phosphorylation (phosphorylation) of Smad2 in frontal cortex associated with antidepressant, convulsion, urological neuroanatomy and hippocampus
1) Confidence 0.80 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15901772 Disease Relevance 0.61 Pain Relevance 0.50
Chronic ECSs (10 d) resulted in a significant increase in activin betaA mRNA expression and Smad2 phosphorylation in both the hippocampus and frontal cortex.
Phosphorylation (phosphorylation) of Smad2 in frontal cortex associated with convulsion, urological neuroanatomy and hippocampus
2) Confidence 0.80 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15901772 Disease Relevance 0.63 Pain Relevance 0.69
The cellular responses to activin are mediated by phosphorylation of a downstream target, Smad2.
Phosphorylation (phosphorylation) of Smad2
3) Confidence 0.80 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15901772 Disease Relevance 0.48 Pain Relevance 0.32
Regulation of activin mRNA and Smad2 phosphorylation by antidepressant treatment in the rat brain: effects in behavioral models.
Phosphorylation (phosphorylation) of Smad2 in brain associated with antidepressant
4) Confidence 0.80 Published 2005 Journal J. Neurosci. Section Title Doc Link 15901772 Disease Relevance 0.52 Pain Relevance 0.53
Chronic fluoxetine did not influence activin betaA expression, but fluoxetine as well as desipramine did increase Smad2 phosphorylation in the frontal cortex.
Phosphorylation (phosphorylation) of Smad2 in frontal cortex associated with desipramine, urological neuroanatomy and fluoxetine
5) Confidence 0.80 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15901772 Disease Relevance 0.62 Pain Relevance 0.80
In this work, we report that TGF-beta-dependent signaling is regulated by electrical activity in developing rat primary myotubes, as determined by Smad2 phosphorylation, Smad4 nuclear translocation, and p3TPLux reporter activity.
Phosphorylation (phosphorylation) of Smad2 in myotubes
6) Confidence 0.59 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16682418 Disease Relevance 0.08 Pain Relevance 0.13
Rather, they were associated with the inhibition of oxidative stress and smad2 phosphorylation.
Phosphorylation (phosphorylation) of smad2 associated with stress
7) Confidence 0.59 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2823698 Disease Relevance 1.48 Pain Relevance 0.37
In addition, we have shown that juglone inhibits the phosphorylation of smad2 an important redox-sensitive, profibrotic signaling molecule in the kidney [7,16,17].
Phosphorylation (phosphorylation) of smad2 in kidney
8) Confidence 0.59 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2823698 Disease Relevance 1.12 Pain Relevance 0.09
-SMA, phospho-smad2 and ?
Phosphorylation (phospho) of smad2
9) Confidence 0.51 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2823698 Disease Relevance 0.07 Pain Relevance 0
Although it is unclear whether the inhibition of smad2 phosphorylation was a direct effect or a downstream event secondary to juglone's antioxidant characteristics in our model, smad2 inhibition has been successful in experimental studies of native and transplants kidney fibrosis [7,16,17].


Phosphorylation (phosphorylation) of smad2 in kidney associated with fibrosis and internal fibrosis
10) Confidence 0.45 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2823698 Disease Relevance 1.03 Pain Relevance 0.08
The current study examines the influence of chronic electroconvulsive seizures (ECSs), as well as chemical antidepressants, on the expression of activin betaA and the phosphorylation of Smad2 in the rat hippocampus and frontal cortex.
Phosphorylation (phosphorylation) of Smad2 in hippocampus associated with antidepressant, convulsion, urological neuroanatomy and hippocampus
11) Confidence 0.27 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15901772 Disease Relevance 0.61 Pain Relevance 0.50
Chronic ECSs (10 d) resulted in a significant increase in activin betaA mRNA expression and Smad2 phosphorylation in both the hippocampus and frontal cortex.
Phosphorylation (phosphorylation) of Smad2 in hippocampus associated with convulsion, urological neuroanatomy and hippocampus
12) Confidence 0.27 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15901772 Disease Relevance 0.63 Pain Relevance 0.69
In this study, we demonstrated that Smad2 and Smad3 were constitutively phosphorylated in activated HSCs, as reported previously (36), and that NIM811 suppressed the phosphorylation of Smad2 and Smad3 (Fig. 6).
Phosphorylation (phosphorylation) of Smad2 associated with cirrhosis
13) Confidence 0.25 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.17 Pain Relevance 0
signalling pathways, NIM811 enhanced the phosphorylation of JNK and p38, but not extracellular signal-regulated kinases 1 and 2, and suppressed the phosphorylation of Smad2 and Smad3, accompanied by increased Smad7 transcription and decreased TGF-?
Phosphorylation (phosphorylation) of Smad2
14) Confidence 0.25 Published 2007 Journal Liver International Section Abstract Doc Link PMC2156109 Disease Relevance 0.53 Pain Relevance 0.09
In this study, we demonstrated that Smad2 and Smad3 were constitutively phosphorylated in activated HSCs, as reported previously (36), and that NIM811 suppressed the phosphorylation of Smad2 and Smad3 (Fig. 6).
Phosphorylation (phosphorylated) of Smad2 associated with cirrhosis
15) Confidence 0.25 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.18 Pain Relevance 0
signal cascades through Smad2 and Smad3 strongly regulate the expression of the type I collagen gene (27), we evaluated the effects of NIM811 on the phosphorylation of Smad2 and Smad3.
Phosphorylation (phosphorylation) of Smad2
16) Confidence 0.25 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.32 Pain Relevance 0
Phosphorylation of mitogen-activated protein kinases (MAPKs), Smad2 and Smad3 was evaluated.
Phosphorylation (Phosphorylation) of Smad2
17) Confidence 0.25 Published 2007 Journal Liver International Section Abstract Doc Link PMC2156109 Disease Relevance 0.90 Pain Relevance 0.13
Treatment with NIM811 significantly suppressed the phosphorylation of Smad2 and Smad3 in a concentration-dependent manner; 0.5 mM NIM811 suppressed the phosphorylation of Smad2 and Smad3 by nearly 70 and 60% respectively (Fig. 6A and B).
Phosphorylation (phosphorylation) of Smad2
18) Confidence 0.25 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.32 Pain Relevance 0
For comparison, the ratios of phosphorylated Smad2 and Smad3 to nonphosphorylated Smad2 and Smad3, respectively, were calculated from the densitometric data.


Phosphorylation (phosphorylated) of Smad2
19) Confidence 0.25 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.11 Pain Relevance 0.07
For comparison, the ratios of phosphorylated Smad2 and Smad3 to nonphosphorylated Smad2 and Smad3, respectively, were calculated from the densitometric data.


Phosphorylation (nonphosphorylated) of Smad2
20) Confidence 0.25 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.12 Pain Relevance 0.07

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