INT127113

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 2.38
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smad2) DNA binding (Smad2) protein complex (Smad2)
transcription factor binding (Smad2) cytoplasm (Smad2)
Anatomy Link Frequency
frontal cortex 5
hippocampus 1
Smad2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Desipramine 4 99.90 Very High Very High Very High
Hippocampus 16 99.48 Very High Very High Very High
fluoxetine 12 99.44 Very High Very High Very High
antidepressant 20 93.64 High High
depression 4 85.28 High High
Eae 12 84.00 Quite High
antagonist 4 63.44 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 12 99.68 Very High Very High Very High
Convulsion 12 99.32 Very High Very High Very High
Depression 4 85.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic ECSs (10 d) resulted in a significant increase in activin betaA mRNA expression and Smad2 phosphorylation in both the hippocampus and frontal cortex.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of Smad2 in frontal cortex associated with convulsion, urological neuroanatomy and hippocampus
1) Confidence 0.68 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15901772 Disease Relevance 0.64 Pain Relevance 0.70
Chronic fluoxetine did not influence activin betaA expression, but fluoxetine as well as desipramine did increase Smad2 phosphorylation in the frontal cortex.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of Smad2 in frontal cortex associated with desipramine, urological neuroanatomy and fluoxetine
2) Confidence 0.68 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15901772 Disease Relevance 0.63 Pain Relevance 0.80
The cellular responses to activin are mediated by phosphorylation of a downstream target, Smad2.
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of Smad2
3) Confidence 0.49 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15901772 Disease Relevance 0.48 Pain Relevance 0.32
Chronic ECSs (10 d) resulted in a significant increase in activin betaA mRNA expression and Smad2 phosphorylation in both the hippocampus and frontal cortex.
Positive_regulation (increase) of in hippocampus Phosphorylation (phosphorylation) of Smad2 in frontal cortex associated with convulsion, urological neuroanatomy and hippocampus
4) Confidence 0.23 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15901772 Disease Relevance 0.64 Pain Relevance 0.70

General Comments

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