INT127125

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Context Info
Confidence 0.81
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 8.24
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Snca) mitochondrion (Snca) histone binding (Snca)
plasma membrane (Snca) cytoskeleton (Snca) nucleus (Snca)
Anatomy Link Frequency
neuronal 1
Snca (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 96 98.64 Very High Very High Very High
projection neuron 2 97.96 Very High Very High Very High
Inflammation 25 97.78 Very High Very High Very High
Neuritis 4 94.04 High High
Morphine 4 85.48 High High
Dopamine 57 83.04 Quite High
amygdala 3 82.84 Quite High
Central nervous system 58 80.40 Quite High
Dorsal horn 3 79.04 Quite High
withdrawal 2 77.48 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 215 99.84 Very High Very High Very High
Disease 479 99.48 Very High Very High Very High
Stress 83 98.74 Very High Very High Very High
Urological Neuroanatomy 72 98.64 Very High Very High Very High
INFLAMMATION 31 97.78 Very High Very High Very High
Toxicity 28 96.08 Very High Very High Very High
Neuritis 4 94.04 High High
Targeted Disruption 24 89.72 High High
Death 69 86.44 High High
Multiple System Atrophy 4 78.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Axonal localization of alpha-synuclein was confirmed by immunofluorescent labeling.
Localization (localization) of alpha-synuclein
1) Confidence 0.81 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15901780 Disease Relevance 0 Pain Relevance 0.80
We used image analysis to quantify alpha-synuclein increase by measuring fluorescence in the IML.
Localization (increase) of alpha-synuclein associated with spinal cord
2) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.91 Pain Relevance 0.48
The inflammation pattern observed indicates that inflammation might not be involved in the propagation of the alteration but is perhaps a consequence of neuronal damage or alpha-synuclein accumulation in situ.
Localization (accumulation) of alpha-synuclein in neuronal associated with inflammation
3) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.57 Pain Relevance 0.23
To investigate whether alpha-synuclein was aggregated, we double stained with alpha-synuclein and Thioflavine-S, a marker for ?
Localization (aggregated) of alpha-synuclein
4) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.22 Pain Relevance 0.04
Despite alpha-synuclein presence in LBs is a histopathological marker for PD, the mechanisms leading to the gradual transition of soluble alpha-synuclein into insoluble LBs or Lewy neuritis are still unknown.
Localization (presence) of alpha-synuclein associated with parkinson's disease, disease and neuritis
5) Confidence 0.40 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 2.28 Pain Relevance 0.13
Additionally, we proved that an increase in free/polymerized tubulin ratio may increase alpha-synuclein oligomerization when a mitochondrial dependent ATP depletion and reactive oxygen species (ROS) generation occurs (Esteves et al., 2009).
Localization (oligomerization) of alpha-synuclein
6) Confidence 0.40 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.29 Pain Relevance 0.03
Besides alpha-synuclein accumulation being evident in alpha-synucleinopathies, its degradation pathway is not well defined.
Localization (accumulation) of alpha-synuclein
7) Confidence 0.40 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 1.09 Pain Relevance 0.04
Mitochondrial dysfunction, oxidative stress or/and proteasome system impairment, were shown to potentiate alpha-synuclein aggregation in sporadic PD models (revised by Arduino et al., 2010).
Localization (aggregation) of alpha-synuclein associated with stress, parkinson's disease and disease
8) Confidence 0.40 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 2.21 Pain Relevance 0.12
Disruption of the ubiquitin proteasomal system and resultant cytoplasmic aggregation of alpha-synuclein has been implicated as a potential cause of Parkinson's disease [36].


Localization (aggregation) of alpha-synuclein associated with disease
9) Confidence 0.09 Published 2008 Journal Mol Pain Section Body Doc Link PMC2525634 Disease Relevance 0.67 Pain Relevance 0

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