INT127128

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.98
Pain Relevance 3.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CNR1, CNR2) signal transducer activity (CNR1, CNR2) aging (CNR1)
response to stress (CNR1)
Anatomy Link Frequency
osteoclasts 2
blood vessels 1
nerves 1
CNR1 (Homo sapiens)
CNR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid 136 99.98 Very High Very High Very High
Cannabinoid receptor 47 99.96 Very High Very High Very High
Pain 145 99.76 Very High Very High Very High
agonist 66 97.68 Very High Very High Very High
gABA 4 96.88 Very High Very High Very High
Analgesic 26 96.44 Very High Very High Very High
Inflammation 72 95.08 Very High Very High Very High
fibrosis 24 94.68 High High
Osteoarthritis 45 94.40 High High
cannabis 50 93.84 High High
Disease Link Frequency Relevance Heat
Pain 193 99.76 Very High Very High Very High
INFLAMMATION 84 95.08 Very High Very High Very High
Fibrosis 22 94.68 High High
Frailty 48 94.40 High High
Hypercalcemia 3 94.20 High High
Vomiting 136 91.08 High High
Nervous System Injury 13 90.60 High High
Hyperalgesia 17 89.24 High High
Pancreatitis 64 86.08 High High
Spasticity 5 85.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we examined the co-expression of the transient receptor potential vanilloid type 1 (TRPV1) and the cannabinoid CB1/CB2 receptors together with N-acylphosphatidylethanolamine-hydrolizing phospholipase D (NAPE-PLD) and fatty acid amide hydrolase (FAAH), the two enzymes responsible of the synthesis and catabolism of anandamide respectively, in human osteoclasts.
CB1 Binding (receptors) of CB2 in osteoclasts associated with cannabinoid
1) Confidence 0.39 Published 2009 Journal Bone Section Abstract Doc Link 19059369 Disease Relevance 0.09 Pain Relevance 0.19
Here, we examined the co-expression of the transient receptor potential vanilloid type 1 (TRPV1) and the cannabinoid CB1/CB2 receptors together with N-acylphosphatidylethanolamine-hydrolizing phospholipase D (NAPE-PLD) and fatty acid amide hydrolase (FAAH), the two enzymes responsible of the synthesis and catabolism of anandamide respectively, in human osteoclasts.
CB1 Binding (receptors) of CB2 in osteoclasts associated with cannabinoid
2) Confidence 0.39 Published 2009 Journal Bone Section Abstract Doc Link 19059369 Disease Relevance 0.09 Pain Relevance 0.19
Because of reported selective affinity for CB1 receptors, the pharmacological actions of NE at CB2 receptors have not been examined.
CB1 Binding (affinity) of CB2
3) Confidence 0.39 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15901805 Disease Relevance 0 Pain Relevance 0.24
Immunohistochemistry of normal human pancreatic tissues revealed weak immunoreactivity for CB1 and CB2 in pancreatic acini, nerves, blood vessels and ductal cells, as previously described (lower insets Figures 1A & 2A;[39]).
CB1 Binding (immunoreactivity) of CB2 in blood vessels
4) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.58 Pain Relevance 0.50
Two CB receptors have been identified in humans (CB1 and CB2) which are recognized exclusively by cannabinoids.
CB1 Binding (recognized) of CB2 associated with cannabinoid
5) Confidence 0.23 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503671 Disease Relevance 0.82 Pain Relevance 0.73
Immunohistochemistry of normal human pancreatic tissues revealed weak immunoreactivity for CB1 and CB2 in pancreatic acini, nerves, blood vessels and ductal cells, as previously described (lower insets Figures 1A & 2A;[39]).
CB1 Binding (immunoreactivity) of CB2 in nerves
6) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.58 Pain Relevance 0.50
Two cannabinoid receptors, CB1 and CB2, are associated with pain modulation (reviewed in [35]).
CB1 Binding (associated) of CB2 associated with pain and cannabinoid receptor
7) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 0.84 Pain Relevance 0.84
Cannabigerol (CBG) displays sub-micromolar affinity for CB1 and CB2 (Gauson et al 2007).
CB1 Binding (affinity) of CB2
8) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503660 Disease Relevance 0.98 Pain Relevance 0.77

General Comments

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